Wednesday, December 22, 2010

Kerr, Wells, Nicholson, Gibbs et al: PAP with HP!

http://www.ncbi.nlm.nih.gov/pubmed/20920129

Respirology. 2010 Nov;15(8):1197-202. doi: 10.1111/j.1440-1843.2010.01848.x.
Alveolar proteinosis with hypersensitivity pneumonitis: a new clinical phenotype.
Verma H, Nicholson AG, Kerr KM, Dempsey OJ, Gibbs AR, Campbell I, Black F, Rassl D, Rice AJ, Renzoni EA, Wells AU, Hansell DM.

Department of Radiology, Royal Marsden Hospital, London, UK.
Abstract
BACKGROUND AND OBJECTIVE: The aim of the present study was to report the features of five patients with concurrent histopathological features of pulmonary alveolar proteinosis (PAP) and hypersensitivity pneumonitis (HP) and their high-resolution CT (HRCT) appearances.

METHODS: Patients with histopathological features of both HP and PAP on surgical lung biopsy referred for tertiary review were retrospectively identified. The pathology and HRCT images were semi-quantitatively scored to evaluate the relative contribution to HP and PAP.

RESULTS: Five patients had histopathological features of HP and PAP but had varied HRCT appearances. All had imaging features of PAP to a varying degree with two patients also showing characteristics of HP but three patients had ill-defined thickened interlobular septa, not typical of either disease.

No comments:

Post a Comment