Cancer Prev Res (Phila). 2011 Jul;4(7):962-72.
The BATTLE to Personalize Lung Cancer Prevention through Reverse Migration.
Gold KA, Kim ES, Lee JJ, Wistuba II, Farhangfar CJ, Hong WK.
Division of Cancer Medicine, Unit 421, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030. email@example.com.
Agents can enter clinical development for cancer prevention either initially or after previous development for a different indication, such as arthritis, with both approaches consuming many years of development before an agent is fully evaluated for cancer prevention. We propose the following, third approach: reverse migration, that is, importing agents, targets, and study designs to personalize interventions and concepts developed in advanced cancer to the setting of cancer prevention. Importing these "ready-made" features from therapy will allow reverse migration to streamline preventive agent development. We recently reported the Biomarker-integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE) trial of personalized lung cancer therapy and now propose the reverse migration development of personalized lung cancer prevention based on the BATTLE model. Cancer Prev Res; 4(7); 962-72. ©2011 AACR.