Tuesday, November 8, 2011

From U Penn: Gene therapy for lung neoplasms--includes other thoracic neoplasms

http://www.ncbi.nlm.nih.gov/pubmed/22054892

Clin Chest Med. 2011 Dec;32(4):865-85. Epub 2011 Oct 7.
Gene therapy for lung neoplasms.
Vachani A, Moon E, Wakeam E, Haas AR, Sterman DH, Albelda SM.
Source
Division of Pulmonary, Allergy & Critical Care Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.

Abstract
Both advanced-stage lung cancer and malignant pleural mesothelioma are associated with a poor prognosis. Advances in treatment regimens for both diseases have had only a modest effect on their progressive course. Gene therapy for thoracic malignancies represents a novel therapeutic approach and has been evaluated in several clinical trials. Strategies have included induction of apoptosis, tumor suppressor gene replacement, suicide gene expression, cytokine-based therapy, various vaccination approaches, and adoptive transfer of modified immune cells. This review considers the clinical results, limitations, and future directions of gene therapy trials for thoracic malignancies.

No comments:

Post a Comment