Curr Gastroenterol Rep. 2012 Apr 13. [Epub ahead of print]
Gastroesophageal Reflux in Cystic Fibrosis: Current Understandings of Mechanisms and Management.
Source
Center for Advanced Research in Neuromuscular Gastrointestinal Disorders, The Ohio State University, Nationwide Children's Hospital, Columbus, OH, 43205, USA, hayat.mousa@nationwidechildrens.org.
Abstract
Cystic fibrosis (CF) is an inherited disease that affects both the lungs and the digestive system in children and adults. Thick mucus fills the gut and blocks lumens of the pancreas and hepatobiliary systems, creating insufficient pancreas function and liver disease. Chronic gastrointestinal (GI) complications, including intestinal obstruction, occur in neonates, and poor digestion and gastroesophageal reflux disease (GERD) in children. Although GI symptoms tend to improve with age, CF and associated GERD eventually create respiratory insufficiency; the only available treatment option at this stage is a bilaterallung transplant, which carries considerable morbidity and mortality. While GERD may reoccur as a complication of lungtransplantation, GERD symptoms are often reduced following a fundoplication.
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