Saturday, July 28, 2012

From West Virginia U: Markers of Sleep-Disordered Breathing and Prediabetes in US Adults

http://www.ncbi.nlm.nih.gov/pubmed/22829819


 2012;2012:902324. Epub 2012 Jul 5.

Markers of Sleep-Disordered Breathing and Prediabetes in US Adults.

Source

Department of Community Medicine, West Virginia University School of Medicine, 1 Medical Center Drive, P.O. Box 9190, Morgantown, WV 26506, USA.

Abstract

Background. 
Prediabetes is a preclinical stage in the hyperglycemia continuum where subjects are at increased risk of developing diabetes. Several studies reported a positive association between markers of sleep-disordered breathing (SDB) and diabetes. However, few studies investigated the relationship between SDB markers and prediabetes. 

Methods. 
We examined 5,685 participants ≥20 years from the National Health and Nutrition Examination Survey (NHANES) 2005-2008. The exposure of interest was SDB markers including sleep duration, snoring, snorting, and daytime sleepiness. The outcome was prediabetes (n = 2058), among subjects free of diabetes. 

Results. 
SDB markers were associated with prediabetes. Compared to those without any sleep disturbance, the multivariable odds ratio (OR) (95% confidence interval (CI)) of prediabetes among those with three or more SDB markers was 1.69 (1.28-2.22). In subgroup analyses, the association between SDB markers and prediabetes was stronger among women (OR (95% CI) = 2.09 (1.36-3.23) when compared to men (1.52 (1.00-2.35)) and was present among non-Hispanic whites (2.66 (1.92-3.69)) and Mexican Americans (1.99 (1.13-3.48)), but not among non-Hispanic blacks (1.10 (0.70-1.73)). 

Conclusion. 
SDB markers were associated with prediabetes. This association was stronger in women and was present mainly in non-Hispanic whites and Mexican Americans.

No comments:

Post a Comment