Overweight Teens at Higher Risk for ESRD
Overweight and obese adolescents are at increased risk for end-stage renal disease (ESRD), according to Israeli researchers.
In a nationwide population-based retrospective study, Asaf Vivante, MD, of the Israeli Defense Forces Medical Corps and Sheba Medical Center, Tel Hashomer, and colleagues analyzed data from 1,194 adolescents aged 17 years who had been examined for fitness for military service between January 1, 1967 and December 31, 1997. These data were linked to the Israeli ESRD registry. The investigators included in their analysis incident cases of treated ESRD from January 1, 1980 to May 31, 2010.
During a mean of about 25 years of follow-up, treated ESRD developed in 874 subjects (713 male and 161 female). Compared with individuals of normal weight, overweight was associated with threefold increased risk for all-cause treated ESRD and obesity was associated with a nearly sevenfold increased risk, after adjusting for gender, country of origin, systolic blood pressure, and period of enrollment in the study, Dr. Vivante's team reported in Archives of Internal Medicine(2012;172:1644-1650). Overweight and obesity were associated with a sixfold and 19-fold increased risk for diabetic ESRD, respectively, and a twofold and threefold increased risk for nondiabetic ESRD.
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