Infidelity at the University of Chicago

http://www.ncbi.nlm.nih.gov/pubmed/23244760

Mol Cell. 2012 Dec 14;48(5):663-4. doi: 10.1016/j.molcel.2012.11.024.

How infidelity creates a sticky situation.

Drummond DA.

Source

Department of Biochemistry & Molecular Biology, University of Chicago, Chicago, IL 60637, USA. dadrummond@uchicago.edu

Abstract

Errors in translation cause cytotoxic protein misfolding and aggregation. In this issue, Ling et al. (2012) show that scavenging or suppression of reactive oxygen species in E. coli reduces the cellular costs of error-induced aggregation.

Copyright © 2012 Elsevier Inc. All rights reserved.

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  Destroy user interface controlProtein aggregation caused by aminoglycoside action is prevented by a hydrogen peroxide scavenger. [Mol Cell. 2012]