Friday, November 20, 2015

Macrophages, Inflammation, and Lung Cancer

 2015 Nov 19. [Epub ahead of print]

Macrophages, Inflammation, and Lung Cancer.

Author information

  • 1British Columbia Cancer Research Centre, Integrative Oncology, Vancouver, British Columbia, Canada ; econway@bccrc.ca.
  • 2British Columbia Cancer Research Centre, Integrative Oncology, Vancouver, British Columbia, Canada ; lpikor@bccrc.ca.
  • 3British Columbia Cancer Research Centre, Integrative Oncology, Vancouver, British Columbia, Canada ; skung@bccrc.ca.
  • 4British Columbia Cancer Research Centre, Integrative Oncology, Vancouver, British Columbia, Canada ; mhamilto@bccrc.ca.
  • 5British Columbia Cancer Research Centre, Integrative Oncology, Vancouver, British Columbia, Canada ; slam@bccrc.ca.
  • 6British Columbia Cancer Research Centre, Integrative Oncology , 675 West 10th Avenue , 10th floor , Vancouver, British Columbia, Canada , V5Z1L3 , 6046758000 ext 7716 , 6046758232 ; wanlam@bccrc.ca.
  • 7British Columbia Cancer Research Centre, Integrative Oncology, Vancouver, British Columbia, Canada ; kbennewi@bccrc.ca.

Abstract

Lung cancer is the leading cause of cancer mortality worldwide, and at only 18%, has one of the lowest 5-year survival rates of all malignancies. With its highly complex mutational landscape, treatment strategies against lung cancer have proved largely ineffective. However with the recent success of immunotherapy trials in lung cancer, there is renewed enthusiasm in targeting the immune component of tumors. Macrophages make up the majority of the immune infiltrate in tumors and are a key cell type linking inflammation and cancer. Although the mechanisms through which inflammation promotes cancer are not fully understood, two connected hypotheses have emerged: an intrinsic pathway, driven by genetic alterations that lead to neoplasia and inflammation, and an extrinsic pathway, driven by inflammatory conditions that increase cancerrisk. Here, we discuss the contribution of macrophages to these pathways and subsequently their roles in established tumors. We highlight studies investigating the association of macrophages with lung cancer prognosis, and discuss emerging therapeutic strategies for targeting macrophages in the tumor microenvironment.

1 comment:

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