Sunday, June 30, 2019

"...the Principle of Psychoprofessional Gravitation..."

Your Professional Decline Is Coming (Much) Sooner Than You Think

Here’s how to make the most of it.


“Unhappy is he who depends on success to be happy,” Alex Dias Ribeiro, a former Formula 1 race-car driver, once wrote. “For such a person, the end of a successful career is the end of the line. His destiny is to die of bitterness or to search for more success in other careers and to go on living from success to success until he falls dead. In this case, there will not be life after success.”

Call it the Principle of Psychoprofessional Gravitation: the idea that the agony of professional oblivion is directly related to the height of professional prestige previously achieved, and to one’s emotional attachment to that prestige. Problems related to achieving professional success might appear to be a pretty good species of problem to have; even raising this issue risks seeming precious. But if you reach professional heights and are deeply invested in being high up, you can suffer mightily when you inevitably fall.




Update on emerging biomarkers in lung cancer

 2019 Jan;11(Suppl 1):S81-S88. doi: 10.21037/jtd.2019.01.46.

Update on emerging biomarkers in lung cancer.

Author information

1
Houston Methodist Hospital, Cancer Center, Houston, Texas, USA.
2
Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
3
Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.

Abstract

There has been considerable progress made in identifying oncogenic driver mutations in advanced lung cancer. The recognition that lung cancer is actually an umbrella classification that is comprised of multiple molecular subgroups has had a profound impact on how medical oncologists make treatment decisions. These mutations are clinically important as available targeted therapies can achieve significant responses and prolonged disease control. This review will summarize the current guidelines for biomarker testing and available therapeutic agents.

Friday, June 28, 2019

The Personal and Professional Consequences of Physician Burnout: A Systematic Review of the Literature

 2019 Jun 19:1077558719856787. doi: 10.1177/1077558719856787. [Epub ahead of print]

The Personal and Professional Consequences of Physician Burnout: A Systematic Review of the Literature.

Author information

1
1 The University of Alabama, Tuscaloosa, AL, USA.
2
2 Virginia Commonwealth University, Richmond, VA, USA.
3
3 University of Malta, Msida, Malta.

Abstract

The well-being of the health care workforce has emerged as both a major concern and as a component of the "quadruple aim" to enable the "triple aim" of improving patient experiences, reducing costs, and improving population health. Physician burnout is problematic given its effects on physicians, patients, health care organizations, and society. Using conservation of resources theory as a frame, we conducted a systematic review of the empirical literature on the relationship of physician burnout with physician personal and professional outcomes that includes 43 articles. Nine outcomes were organized into three categories illustrating burnout as a dynamic loss spiral rather than a static end-state. Findings show that emotional exhaustion had the greatest impact with the outcomes explored, while depersonalization and lack of professional accomplishment manifested fewer associations. The results suggest that burnout is a complex, dynamic phenomenon, which unfolds over time. Future research and implications of these results are discussed.

Weight discrimination is unacceptable

Weight discrimination is unacceptable

Although legal protections are needed to prevent weight discrimination, the conversation also needs to address the stigmatization of obesity. Despite obesity being recognized as a disease by the American Medical Association since 2013, weight bias continues to exist within society, as well as within the medical community. Obese individuals experience this bias at an early age. Most children who are obese admit to being teased at some point in their childhood. Obesity is a mutifactorial disorder and is not caused by a “lack of willpower.”

Obesity: How diet changes the brain and promotes overeating

Obesity: How diet changes the brain and promotes overeating


Whereas LHAVglut2 neurons from control mice maintained their responsivity to sucrose consumption, LHAVglut2 neurons from [the high fat diet] mice became progressively less responsive to sucrose consumption and less active at rest," the team writes in the study paper.
In other words, the neurons did not send such a strong "stop eating" signal to the brain when the mice consumed sugar or when the mice were resting. Instead, the animals overate and developed obesity.


 

Radio-Frequency Identification Specimen Tracking to Improve Quality in Anatomic Pathology

Andrew P. NorganMD, PhDKurt E. SimonMBA, PMPBarbara A. FeehanCBAPLynn L. SaariMSN, RN, CPANJoseph M. DopplerMT(ASCP), CLSp(MB)G. Scott WelderMAJohn A. SedarskiBSChristopher T. YochMAINneka I. ComfereMD;John A. MartinMDBrian J. BartholmaiMDR. Ross ReichardMD
From the Departments of Laboratory Medicine and Pathology (Drs Norgan, Comfere, and Reichard, Messrs Simon, Sedarski, and Yoch, and Ms Feehan), Nursing (Ms Saari), Dermatology (Messrs Doppler and Welder and Dr Comfere), and Radiology (Dr Bartholmai) and the Division of Gastroenterology and Hepatology (Dr Martin), Mayo Clinic, Rochester, Minnesota.
The authors have no relevant financial interest in the products or companies described in this article.
Corresponding author: R. Ross Reichard, MD, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (email: ).
Context.— Preanalytic errors, including specimen-labeling errors and specimen loss, occur frequently during specimen collection, transit, and accessioning. Radio-frequency identification tags can decrease specimen identification and tracking errors through continuous and automated tracking of specimens.
Objective.— To implement a specimen-tracking infrastructure to reduce preanalytic errors (specimen mislabeling or loss) between specimen collection and laboratory accessioning. Specific goals were to decrease preanalytic errors by at least 70% and to simultaneously decrease employee effort dedicated to resolving preanalytic errors or investigating lost specimens.
Design.— A radio-frequency identification specimen-tracking system was developed. Major features included integral radio-frequency identification labels (radio-frequency identification tags and traditional bar codes in a single printed label) printed by point-of-care printers in collection suites; dispersed radio-frequency identification readers at major transit points; and systems integration of the electronic health record, laboratory information system, and radio-frequency identification tracking system to allow for computerized physician order entry–driven label generation, specimen–transit-time tracking, interval-based alarms, and automated accessioning.
Results.— In the 6-month postimplementation period, 6 mislabeling events occurred in collection areas using the radio-frequency identification system, compared with 24 events in the 6-month preimplementation period (75% decrease; P = .001). In addition, the system led to the timely recovery of 3 lost specimens. Labeling expenses were decreased substantially in the transition from high-frequency to ultrahigh-frequency radio-frequency identification tags.
Conclusions.— Radio-frequency identification specimen tracking prevented several potential specimen-loss events, decreased specimen recovery time, and decreased specimen-labeling errors. Increases in labeling/tracking expenses for the system were more than offset by time savings and loss avoidance though error mitigation.

Saturday, June 22, 2019

Micropapillary adenocarcinoma of lung: Morphological criteria and diagnostic reproducibility among pulmonary pathologists

 2019 Apr 24;41:43-50. doi: 10.1016/j.anndiagpath.2019.04.008. [Epub ahead of print]

Micropapillary adenocarcinoma of lung: Morphological criteria and diagnostic reproducibility among pulmonary pathologists.

Author information

1
Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, USA.
2
Health Sciences Research Department, Mayo Clinic, Rochester, MN, USA.
3
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
4
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
5
Department of Pathology, The University of Mississippi Medical Center, MS, USA.
6
Department of Pathology, Harvard Medical School, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
7
Department of Anatomic Pathology, The Mount Sinai Hospital, New York, NY, USA.
8
Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, USA.
9
Kaiser Permanente, Santa Clara Medical Center and Medical Offices, Santa Clara, CA, USA.
10
Department of Pathology, Mayo Clinic, Phoenix, AZ, USA.
11
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
12
Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, USA; Health Sciences Research Department, Mayo Clinic, Rochester, MN, USA.
13
Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, USA. Electronic address: JaeRo@houstonmethodist.org.

Abstract

CONTEXT:

Invasive micropapillary adenocarcinoma (MPC) is an aggressive variant of lung adenocarcinoma, frequently manifesting with advanced stage lymph node metastasis and decreased survival.

OBJECTIVE:

Identification of this morphology is important, as it is strongly correlated with poor prognosis regardless of the amount of MPC component. To date, no study has investigated the morphological criteria used to objectively diagnose it.

DESIGN:

Herein, we selected 30 cases of potential MPC of lung, and distributed 2 digital images per case among 15 pulmonary pathology experts. Reviewers were requested to diagnostically interpret, assign the percentage of MPC component, and record the morphological features they identified. The noted features included: columnar cells, elongated slender cell nests, extensive stromal retraction, lumen formation with internal epithelial tufting, epithelial signet ring-like forms, intracytoplasmic vacuolization, multiple nests in the same alveolar space, back-to-back lacunar spaces, epithelial nest anastomosis, marked pleomorphism, peripherally oriented nuclei, randomly distributed nuclei, small/medium/large tumor nest size, fibrovascular cores, and spread through air-spaces (STAS).

RESULTS:

Cluster analysis revealed three subgroups with the following diagnoses: "MPC", "combined papillary and MPC", and "others". The subgroups correlated with the reported median percentage of MPC. Intracytoplasmic vacuolization, epithelial nest anastomosis/confluence, multiple nests in the same alveolar space, and small/medium tumor nest size were the most common criteria identified in the cases diagnosed as MPC. Peripherally oriented nuclei and epithelial signet ring-like forms were frequently identified in both the "MPC" and "combined papillary and MPC" groups.

CONCLUSIONS:

Our study provides objective diagnostic criteria to diagnose MPC of lung.

Sunday, June 2, 2019

I am a practicing pathologist and currently serve on the College of American Pathologists Board of Governors. I am a Candidate for the College of American Pathologists' President-Elect, 2019-2021 term. My vision is here.

I am a practicing pathologist and currently serve on the College of American Pathologists Board of Governors.  I am a Candidate for the College of American Pathologists' President-Elect, 2019-2021 term.  My vision is here.

Membership Growth. Pathologist Payment.

The Trust Revolution How the Digitization of Trust Will Revolutionize Business and Government - Todd Henderson and Salen Churi

The Trust Revolution

How the Digitization of Trust Will Revolutionize Business and Government



M.Todd HendersonUniversity of Chicago , Salen ChuriTrust Ventures


The Trust Revolution



Book description

While conventional wisdom dictates that people's trust – in the government, in corporations, in each other - is at a historic low, the rise of the internet is offering new ways to rehabilitate and strengthen trust. Uber is probably the best example of a new company that, on the surface, allows individuals with smartphones to get rides with strangers, but at a deeper level is in the business of trust. In The Trust Revolution, M. Todd Henderson and Salen Churi trace the history of innovation and trust, linking companies such as Uber with medieval guilds, early corporations, self-regulatory organizations, and New-Deal era administrative agencies. This book should be read by anyone who wants to understand how trust - and its means of creation - has the potential not only to expand opportunities for human cooperation, but also to reduce the size and scope of government and corporate control over our lives.