Sunday, March 3, 2013

The Contralateral Prophylactic Mastectomy Decision-Making Process

http://www.ncbi.nlm.nih.gov/pubmed/23446503


 2013 Jan;33(1):11-21.

The Contralateral Prophylactic Mastectomy Decision-Making Process.

Source

Sandra K. Baker, MSN, WHNP-BC, is an advanced practice Women's Health Nurse Practitioner with special interest in breast care. Sandra's nursing experience includes 10 years in high-risk obstetrics. She is currently working at UNC Women's Specialty Center. Deborah K. Mayer, PhD, RN, AOCN, FAAN, is an advanced practice oncology nurse who has consulted with organizations on issues to improve cancer care and has more than 35 years of cancer nursing practice, education, research, and management experience. Mayer is a member of the Adult and Geriatric Health Division in the UNC-CH SON and the Lineberger Comprehensive Cancer Center. Her program of research focuses on the issues facing cancer survivors and improving cancer care. She has a clinical practice working with breast cancer survivors. Noreen Esposito, EdD, WHNP, FNP, PMHNP-BC, is Psychiatric Mental Health NP and a WHNP, Clinical Associate Professor of Nursing at the University of North Carolina at Chapel Hill, and the coordinator of the WHNP graduate program, and has a faculty practice in the Women's Mood Disorder Clinic at UNC Hospitals.

Abstract

Women facing an early-stage breast cancer diagnosis may elect to have a contralateral prophylactic mastectomy (CPM) to reduce the risk of developing a contralateral breast cancer. In the United States, CPM rates for all surgically treated women with stages I through III unilateral breast cancer increased dramatically from 1998 to 2003. In 1991, the National Institutes of Health Consensus Panel concluded that breast-conserving surgery is an appropriate and preferred treatment for the majority of women with stage I and II breast cancer because it provides survival rates equivalent to those of total mastectomy while preserving the breast. Owing to the near equivalence of the 2 surgical treatment options in terms of survival benefit and recurrence risk, surgical treatment for early-stage breast cancer qualifies as a "preference-sensitive decision" for which no one treatment is best (S. T. ; ). We performed a literature review to identify studies that examined CPM decision making in women facing an early-stage breast cancer diagnosis with the aim of determining the most influential factors affecting her surgical choice. Study outcome measures were largely based on demographic information retrospectively extracted from large databases representing trends rather than revealing influences reflecting preference-sensitive decision making. While we may know demographically, which women choose CPM, we do not know why. To better understand this increasing trend, which greatly impacts patient counseling, prospective research is needed using decision quality methods developed to illuminate factors influencing a woman's decision.

Gravity separation of fat, somatic cells, and bacteria in raw and pasteurized milks

http://www.ncbi.nlm.nih.gov/pubmed/23415516


 2013 Feb 14. pii: S0022-0302(13)00115-X. doi: 10.3168/jds.2012-6006. [Epub ahead of print]

Gravity separation of fat, somatic cells, and bacteria in raw and pasteurized milks.

Source

Northeast Dairy Food Research Center, Department of Food Science, Cornell University, Ithaca, NY 14853.

Abstract

The objective of experiment 1 was to determine if the extent of gravity separation of milk fat, bacteria, and somatic cells is influenced by the time and temperature of gravity separation or the level of contaminating bacteria present in the raw milk. The objective of experiment 2 was to determine if different temperatures of milk heat treatment affected the gravity separation of milk fat, bacteria, and somatic cells. In raw milk, fat, bacteria, and somatic cells rose to the top of columns during gravity separation. About 50 to 80% of the fat and bacteria were present in the top 8% of the milk after gravity separation of raw milk. Gravity separation for 7 h at 12°C or for 22 h at 4°C produced equivalent separation of fat, bacteria, and somatic cells. The completeness of gravity separation of fat was influenced by the level of bacteria in the milk before separation. Milk with a high bacterial count had less (about 50 to 55%) gravity separation of fat than milk with low bacteria count (about 80%) in 22 h at 4°C. Gravity separation caused fat, bacteria, and somatic cells to rise to the top of columns for raw whole milk and high temperature, short-time pasteurized (72.6°C, 25 s) whole milk.Pasteurization at ≥76.9°C for 25 s prevented all 3 components from rising, possibly due to denaturation of native bovine immunoglobulins that normally associate with fat, bacteria, and somatic cells during gravity separation. Gravity separation can be used to produce reduced-fat milk with decreased bacterial and somatic cell counts, and may be a critical factor in the history of safe and unique traditional Italian hard cheeses produced from gravity-separated raw milk. A better understanding of the mechanism of this natural process could lead to the development of new nonthermal thermal technology (that does not involve heating the milk to high temperatures) to remove bacteria and spores from milk or other liquids.

Respiratory bacterial infections in cystic fibrosis

http://www.ncbi.nlm.nih.gov/pubmed/23449384


 2013 Feb 27. [Epub ahead of print]

Respiratory bacterial infections in cystic fibrosis.

Source

aInstitute of International Health, Immunology and Microbiology, Unit of Bacteriology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen bDepartment of Paediatrics, Cystic Fibrosis Centre Copenhagen cDepartment of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Denmark.

Abstract

PURPOSE OF REVIEW:

Bacterial respiratory infections are the main cause of morbidity and mortality in patients with cystic fibrosis (CF). Pseudomonas aeruginosa remains the main pathogen in adults, but other Gram-negative bacteria such as Achromobacter xylosoxidans and Stenotrophomonas maltophilia as well as nontuberculous mycobacteria have been shown to play an important role in the lung disease. The purpose of this review is to summarize the knowledge on disease and treatment of infection with CF-related pathogens.

RECENT FINDINGS:

The role of the paranasal sinuses as a source of infection and site of bacterial adaptation has been recognized. This review will focus on the different conditions encountered by the bacteria in sinuses and lung, as well as the principles of treatment in the different infection sites.

SUMMARY:

Chronic, pulmonary infections remain the single most prominent cause of the increased morbidity and mortality in CF. After the increasing efficiency of anti-P. aeruginosa treatment, newer pathogens have been identified, with individual clinical characteristics. Microbiological surveillance is very important in keeping the patients stable. Samples from both the lower and upper respiratory tract (nasal sampling) should be investigated and both infection sites should be treated.

From Chest: Epidemic of Lung Cancer in Patients With HIV Infection (my take: role of smoking being undervalued)

http://www.ncbi.nlm.nih.gov/pubmed/23381313


 2013 Feb 1;143(2):305-14. doi: 10.1378/chest.12-1699.

Epidemic of Lung Cancer in Patients With HIV Infection.

Abstract

The survival of patients with HIV infection has improved dramatically over the past 20 years, largely owing to a significant reduction in opportunistic infections and AIDs-defining malignancies, such as lymphoma and Kaposi sarcoma. However, with improved survival, patients with HIV are experiencing morbidity and mortality from other (non-AIDs-defining) complications, such as solid organ malignancies. Of these, the leading cause of mortality in the HIV-infected population is lung cancer, accounting for nearly 30% of all cancer deaths and 10% of all non-HIV-related deaths. Importantly, the average age of onset of lung cancer in the HIV-infected population is 25 to 30 years earlier than that in the general population and at lower exposure to cigarette smoke. This article provides an overview of the epidemiology of lung cancer in the HIV-infected population and discusses some of the important risk factors and pathways that may enhance the risk of lung cancer in this population.

Meningitis: Drug companies' lobbyist efforts grow for stricter regulation of compounder pharmacies; "costing them millions of dollars in annual profits"

http://www.voxxi.com/lobby-stricter-compounder-regulation/

Lobbyist efforts grow for stricter regulation of compounder pharmacies


Drug companies have ramped up lobbying efforts in Congress to force specialty pharmacies to either stop mass-producing drugs or face stricter regulation.
Commercial drug makers are also trying to prevent these specialty pharmacies, known as compounders, from making “knockoff” drugs for people and their pets that the companies say are costing them millions of dollars in annual profits, records and interviews show.



Read more: http://www.voxxi.com/lobby-stricter-compounder-regulation/#ixzz2MTlpu3Fp - See more at: http://www.voxxi.com/lobby-stricter-compounder-regulation/#sthash.xWZZe8rj.dpuf


Of Mice and Men: From the NIH: Mouse model of chronic and binge ethanol feeding

http://www.ncbi.nlm.nih.gov/pubmed/23449255

 2013 Feb 28;8(3):627-37. doi: 10.1038/nprot.2013.032. Epub 2013 Feb 28.

Mouse model of chronic and binge ethanol feeding (the NIAAA model).

Source

Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), Bethesda, Maryland, USA.

Abstract

Chronic alcohol consumption is a leading cause of chronic liver disease worldwide, leading to cirrhosis and hepatocellular carcinoma. Currently, the most widely used model for alcoholic liver injury is ad libitum feeding with the Lieber-DeCarli liquid diet containing ethanol for 4-6 weeks; however, this model, without the addition of a secondary insult, only induces mild steatosis, slight elevation of serum alanine transaminase (ALT) and little or no inflammation. Here we describe a simple mouse model of alcoholic liver injury by chronic ethanol feeding (10-d ad libitum oral feeding with the Lieber-DeCarli ethanol liquid diet) plus a single binge ethanol feeding. This protocol for chronic-plus-single-binge ethanol feeding synergistically induces liver injury, inflammation and fatty liver, which mimics acute-on-chronic alcoholic liver injury in patients. This feeding protocol can also be extended to chronic feeding for longer periods of time up to 8 weeks plus single or multiple binges. Chronic-binge ethanol feeding leads to high blood alcohollevels; thus, this simple model will be very useful for the study of alcoholic liver disease (ALD) and of other organs damaged by alcohol consumption.

Blood Alcohol Level tests in nightlife recreational settings as a (poor) preventive tool




 2013 Jan;41(1):10-16. Epub 2013 Jan 1.

Blood Alcohol Level tests in nightlife recreational settings as a preventive tool.

Source

Instituto Europeo de Estudios en PrevenciĂłn (IREFREA).

Abstract

Background: Getting drunk is a common practice in the nightlife context and is related to risk behaviors. One potentially preventive strategy would be to conduct breathalyzer (blood alcohol content level-BAC) tests in situ, encouraging the young people to take responsibility. The aim of this study is to evaluate the efficacy of such a measure.
 Method: A sample of 555 young people were interviewed in the most popular nightlife recreational areas in three Spanish cities. After they answered to a brief questionnaire, the breathalyzer test was done and they were then informed of the results and also informed about the results, telling them what the maximum authorized rate of alcohol in expired air was for driving. After, they were asked about their drinking intentions for the rest of the night, and if they we going to be driving. 
Results: Only 21.6% stated that they would stop drinking or drink less, while a similar percentage (21.5%) said they would drink even more than they had intended after finding out their BAC. The logistic regression indicated that the decision to drink more or less was influenced by the BAC level, the amount they had planned to drink prior to the test and high scores on "sensation seeking." Those who decided to drive had lower BAC levels and had planned to drink less prior to the interview. 
Conclusions: Prevention strategies involving attempts to change behavior through informing drinkers of their own BAC are controversial, since although for some it leads to their drinking less, in other cases the young people end up drinking more than they had planned.

Saturday, March 2, 2013

Nicotine might have a protective effect in the etiology of multiple sclerosis

http://www.ncbi.nlm.nih.gov/pubmed/23319071


 2013 Jan 14. [Epub ahead of print]

Nicotine might have a protective effect in the etiology of multiple sclerosis.

Source

Institute of Environmental Medicine, Karolinska Institutet, Sweden.

Abstract

OBJECTIVE:

The use of moist snuff is common in Sweden and leads to exposure to high doses of nicotine. Recent studies indicate that exposure to nicotine could modulate immune responses. The aim of this study was to investigate the influence of snuff use on the risk of developing multiple sclerosis (MS), taking smoking habits into consideration.

METHODS:

In two Swedish population-based, case-control studies (7883 cases, 9437 controls), subjects with different snuff use habits were compared regarding MS risk, by calculating odds ratios (ORs) with 95% confidence intervals (CIs).

RESULTS:

Snuff-takers have a decreased risk of developing MS compared with those who have never used moist snuff (OR 0.83, 95% CI 0.75-0.92), and we found clear evidence of an inverse dose-response correlation between cumulative dose of snuff use and the risk of developing the disease. We further observed that subjects who combined smoking and snuff use had a significantly lower risk for MS than smokers who had never used moistsnuff, also after adjustment for amount of smoking.

CONCLUSIONS:

Our results add evidence to the hypothesis that nicotine exerts anti-inflammatory and immune-modulating effects in a way that might decrease the risk of developing MS.

Medical Prosecutors

http://www.ncbi.nlm.nih.gov/pubmed/23447904


 2012 Dec;31(4):567-88.

The role of criminal law within the healthcare sector.

Source

University of Applied Science Leiden, P.O. 382, 2300 AJ Leiden, The Netherlands. yasminalhafaji@airpost.net

Abstract

Health is for most of us the most precious thing one can have. However, in practice situations occur where the patient is harmed within the healthcare institution. Traditionally, there are several ways to protect individuals in society: with civil, criminal and administrative procedures. Over the years in the Netherlands complaints procedures were established in which the complaints about healthcare providers' performance can be handled. Recently, there are some developments within the criminal law that concern the healthcare sector. Examples are: the establishment of the Public Prosecution Service's Expertise Center on Medical Matters, appointments of medical prosecutors. In addition, in legal literature suggestions are made that criminal law is nowadays applied in order to provide redress to the patients (relatives) and as a 'safety tool' that is to ensure security and to counter the risks within the healthcare sector. The article discusses the role of criminal law within the healthcare sector, and in particular, whether criminal procedure is suitable for handling complaints about healthcare.

Islamic Law and Porcine Products in Vaccines

http://www.ncbi.nlm.nih.gov/pubmed/23445524


 2013 Feb 28. doi: 10.1111/bioe.12016. [Epub ahead of print]

Dire Necessity and Transformation: Entry-points for Modern Science in Islamic Bioethical Assessment of Porcine Products in Vaccines.

Abstract

The field of medicine provides an important window through which to examine the encounters between religion and science, and between modernity and tradition. While both religion and science consider health to be a 'good' that is to be preserved, and promoted, religious and science-based teachings may differ in their conception of what constitutes good health, and how that health is to be achieved. This paper analyzes the way the Islamic ethico-legal tradition assesses the permissibility of using vaccines that contain porcine-derived components by referencing opinions of several Islamic authorities. In the Islamic ethico-legal tradition controversy surrounds the use of proteins from an animal (pig) that is considered to be impure by Islamic law. As we discuss the Islamic ethico-legal constructs used to argue for or against the use of porcine-based vaccines we will call attention to areas where modern medical data may make the arguments more precise. By highlighting areas where science can buttress and clarify the ethico-legal arguments we hope to spur an enhanced applied Islamic bioethics discourse where religious scholars and medical experts use modern science in a way that remains faithful to the epistemology of Islamic ethics to clarify what Islam requires of Muslim patients and healthcare workers.

Telephone requests for eye and tissue donation: concerns expressed by families and the impact of the donor registry

http://www.ncbi.nlm.nih.gov/pubmed/23448828


 2013 Mar;23(1):92-8. doi: 10.7182/pit2013948.

Telephone requests for donation: concerns expressed by families and the impact of the donor registry.

Source

Verble, Worth and Verble, Lexington, Kentucky.

Abstract

Context-The request process for eye and tissue donation is different from the process that families of organ donors experience, but the research into eye/tissue-only decision making has been sparse.
Objective-To determine the concerns of families approached over the phone for eye/tissue donations and to study the impact of the donor registry on those decisions.
Design, Setting and Participants-Written instrument filled out by family services coordinators while speaking with families about donation via phone in the San Diego, California, area during 2011.
Main Outcome Measures-Responses marked on a 21-item instrument, contextual notes, donor registrations, and decisions made.Results-With a 60% refusal rate, the most common reasons reported for declining donation are that the potential donor said during life he/she did not want to donate (26%) or that the family, not knowing the potential donor's wishes, opted not to donate (13%). Other specific reasons for not donating were as follows: wanting the body buried whole (8%), concerns about age and prior health (7%), and incompatibility with religion or culture (7%). Consenting families had different concerns: worries about delays (36%), the potential donors' age and health (25%), how the body might look for viewing (14%), the amount of paperwork (10%), for-profit status of beneficiaries (9%), international distribution (8%), and family disunity (8%). Registry-related refusals weighted against donations of tissues from registered donors amounted to a deficit of 92 potential donations. When donations lost to faulty assumptions based on public education are added, the deficit increases to 122 lost donations.

End-of-life decision-making in intensive care: "luck of the draw" doesn't cut it. We must address this now.

http://www.ncbi.nlm.nih.gov/pubmed/23435951

 2013 Feb 22. [Epub ahead of print]

The luck of the draw: physician-related variability in end-of-life decision-making in intensive care.

Source

Discipline of Obstetrics and Gynecology, Women's and Children's Hospital, University of Adelaide, 72 King William Rd, North Adelaide, SA, 5006, Australia, dominic.wilkinson@adelaide.edu.au.

Abstract

PURPOSE:

To critically analyze physician-related variability in end-of-life decision-making in intensive care.

METHODS:

An ethical analysis of factors contributing to physician-related variability in end-of-life decision-making.

RESULTS:

There is variability in decision-making about life support, both within and between intensive care units. Physician age, race, religion, attitude to risk, and personality factors have been associated with decisions to provide or limit life-sustaining treatment, though it is unclear how much these factors affect patient outcome. Inconsistency in decision-making appears worryingly arbitrary, and may mean that patients' values are sometimes being ignored or overridden. However, physician influence on decisions may also sometimes be appropriate and unavoidable, particularly where patient values are unclear.

CONCLUSIONS:

We argue that, although physician-related variability in end-of-life care can never be eliminated entirely, it is potentially ethically problematic. We outline four potential strategies for reducing the "roster lottery."

"Efforts to influence utilization of services to bring down spending and to improve quality of care have largely failed"

http://www.ncbi.nlm.nih.gov/pubmed/23448915


 2013 Apr;36(2):88-107. doi: 10.1097/JAC.0b013e31828596de.

Open questions concerning influences on clinical decision making.

Source

Boston University School of Management, Boston, Massachusetts.

Abstract

Efforts to influence utilization of services to bring down spending and to improve quality of care have largely failed. A critical reason is that most attention has focused on dysfunctional financial incentives without considering other factors that also influence physicians' utilization decisions. In this article, after providing a framework for ideal physician-patient interactions, questions are also raised about other influences, including physicians' impulse to help patients, professional codes of ethics, the threat of malpractice claims, and the leadership of health care organizations. An Appendix contains a summary of the literature on these factors.

Medicalized social hygiene? Tuberculosis policy in the German Democratic Republic

http://www.ncbi.nlm.nih.gov/pubmed/23241911


 2012 Fall;86(3):394-423. doi: 10.1353/bhm.2012.0059.

Medicalized social hygiene? Tuberculosis policy in the German Democratic Republic.

Source

History Department, Carnegie Mellon University, Pittsburgh, PA, USA.

Abstract

This archive-based study investigates tuberculosis policy in the German Democratic Republic (GDR) from the 1940s to the 1960s. The focus is on the sanatorium as the major site of treatment and on BCG vaccination as the major preventive tool. The article tests and accepts the thesis that the GDR's guiding health paradigm is best described by the term "medicalized social hygiene." The article finds that methods of both treatment and prevention were characterized less by radical change and innovation than by tradition and pragmatism at least until the mid-1950s. Thus, "forced institutionalization" of "asocial" patients continued after 1945. Yet the health ministry long hesitated to make BCG vaccination obligatory. The German past, the Cold War context of German-German rivalry, and medical and popular attitudes toward vaccination, TB, and TB patients are considered as possible explanations for the mix of continuity and change in TB policy.

Need another reason to work out? "In healthy older men, preservation of whole brain volume (i.e. less atrophy) is associated with larger muscle size"

http://www.ncbi.nlm.nih.gov/pubmed/23446137


 2013 Feb 28;13(1):20. [Epub ahead of print]

Neck muscle cross-sectional area, brain volume and cognition in healthy older men; a cohort study.

Abstract

BACKGROUND:

Two important consequences of the normal ageing process are sarcopenia (the age-related loss of muscle mass and function) and age-related cognitive decline. Existing data support positive relationships between muscle function, cognition and brain structure. However, studies investigating these relationships at older ages are lacking and rarely include a measure of muscle size. Here we test whether neck muscle size is positively associated with cognition and brain structure in older men.

METHODS:

We studied 51 healthy older men with mean age 73.8 (sd 1.5) years. Neck muscle cross-sectional area (CSA) was measured from T1-weighted MR-brain scans using a validated technique. We measured multiple cognitive domains including verbal and visuospatial memory, executive functioning and estimated prior cognitive ability. Whole brain, ventricular, hippocampal and cerebellar volumes were measured with MRI. General linear models (ANCOVA) were performed.

RESULTS:

Larger neck muscle CSA was associated with less whole brain atrophy (t = 2.86, p = 0.01, partial eta squared 17%). Neck muscle CSA was not associated with other neuroimaging variables or current cognitive ability. Smaller neck muscle CSA was unexpectedly associated with higher prior cognition (t = -2.12, p < 0.05, partial eta squared 10%).

CONCLUSIONS:

In healthy older men, preservation of whole brain volume (i.e. less atrophy) is associated with larger muscle size. Longitudinal ageing studies are now required to investigate these relationships further.