Sunday, June 30, 2019

"...the Principle of Psychoprofessional Gravitation..."

Your Professional Decline Is Coming (Much) Sooner Than You Think

Here’s how to make the most of it.


“Unhappy is he who depends on success to be happy,” Alex Dias Ribeiro, a former Formula 1 race-car driver, once wrote. “For such a person, the end of a successful career is the end of the line. His destiny is to die of bitterness or to search for more success in other careers and to go on living from success to success until he falls dead. In this case, there will not be life after success.”

Call it the Principle of Psychoprofessional Gravitation: the idea that the agony of professional oblivion is directly related to the height of professional prestige previously achieved, and to one’s emotional attachment to that prestige. Problems related to achieving professional success might appear to be a pretty good species of problem to have; even raising this issue risks seeming precious. But if you reach professional heights and are deeply invested in being high up, you can suffer mightily when you inevitably fall.




Spyro Gyra - Morning Dance

Spyro Gyra - Morning Dance

Update on emerging biomarkers in lung cancer

 2019 Jan;11(Suppl 1):S81-S88. doi: 10.21037/jtd.2019.01.46.

Update on emerging biomarkers in lung cancer.

Author information

1
Houston Methodist Hospital, Cancer Center, Houston, Texas, USA.
2
Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
3
Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.

Abstract

There has been considerable progress made in identifying oncogenic driver mutations in advanced lung cancer. The recognition that lung cancer is actually an umbrella classification that is comprised of multiple molecular subgroups has had a profound impact on how medical oncologists make treatment decisions. These mutations are clinically important as available targeted therapies can achieve significant responses and prolonged disease control. This review will summarize the current guidelines for biomarker testing and available therapeutic agents.

"'If we want to keep people out of hospital, then we need to think about prevention, wellness, health, exercise, [and] fitness.' But that may be easier said than done."

Nearly 50 per cent of Australians now have a chronic disease — many of them preventable


"If we want to keep people out of hospital, then we need to think about prevention, wellness, health, exercise, fitness."
But that may be easier said than done.

Friday, June 28, 2019

The Personal and Professional Consequences of Physician Burnout: A Systematic Review of the Literature

 2019 Jun 19:1077558719856787. doi: 10.1177/1077558719856787. [Epub ahead of print]

The Personal and Professional Consequences of Physician Burnout: A Systematic Review of the Literature.

Author information

1
1 The University of Alabama, Tuscaloosa, AL, USA.
2
2 Virginia Commonwealth University, Richmond, VA, USA.
3
3 University of Malta, Msida, Malta.

Abstract

The well-being of the health care workforce has emerged as both a major concern and as a component of the "quadruple aim" to enable the "triple aim" of improving patient experiences, reducing costs, and improving population health. Physician burnout is problematic given its effects on physicians, patients, health care organizations, and society. Using conservation of resources theory as a frame, we conducted a systematic review of the empirical literature on the relationship of physician burnout with physician personal and professional outcomes that includes 43 articles. Nine outcomes were organized into three categories illustrating burnout as a dynamic loss spiral rather than a static end-state. Findings show that emotional exhaustion had the greatest impact with the outcomes explored, while depersonalization and lack of professional accomplishment manifested fewer associations. The results suggest that burnout is a complex, dynamic phenomenon, which unfolds over time. Future research and implications of these results are discussed.

Weight discrimination is unacceptable

Weight discrimination is unacceptable

Although legal protections are needed to prevent weight discrimination, the conversation also needs to address the stigmatization of obesity. Despite obesity being recognized as a disease by the American Medical Association since 2013, weight bias continues to exist within society, as well as within the medical community. Obese individuals experience this bias at an early age. Most children who are obese admit to being teased at some point in their childhood. Obesity is a mutifactorial disorder and is not caused by a “lack of willpower.”

Obesity: How diet changes the brain and promotes overeating

Obesity: How diet changes the brain and promotes overeating


Whereas LHAVglut2 neurons from control mice maintained their responsivity to sucrose consumption, LHAVglut2 neurons from [the high fat diet] mice became progressively less responsive to sucrose consumption and less active at rest," the team writes in the study paper.
In other words, the neurons did not send such a strong "stop eating" signal to the brain when the mice consumed sugar or when the mice were resting. Instead, the animals overate and developed obesity.


 

Radio-Frequency Identification Specimen Tracking to Improve Quality in Anatomic Pathology

Andrew P. NorganMD, PhDKurt E. SimonMBA, PMPBarbara A. FeehanCBAPLynn L. SaariMSN, RN, CPANJoseph M. DopplerMT(ASCP), CLSp(MB)G. Scott WelderMAJohn A. SedarskiBSChristopher T. YochMAINneka I. ComfereMD;John A. MartinMDBrian J. BartholmaiMDR. Ross ReichardMD
From the Departments of Laboratory Medicine and Pathology (Drs Norgan, Comfere, and Reichard, Messrs Simon, Sedarski, and Yoch, and Ms Feehan), Nursing (Ms Saari), Dermatology (Messrs Doppler and Welder and Dr Comfere), and Radiology (Dr Bartholmai) and the Division of Gastroenterology and Hepatology (Dr Martin), Mayo Clinic, Rochester, Minnesota.
The authors have no relevant financial interest in the products or companies described in this article.
Corresponding author: R. Ross Reichard, MD, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (email: ).
Context.— Preanalytic errors, including specimen-labeling errors and specimen loss, occur frequently during specimen collection, transit, and accessioning. Radio-frequency identification tags can decrease specimen identification and tracking errors through continuous and automated tracking of specimens.
Objective.— To implement a specimen-tracking infrastructure to reduce preanalytic errors (specimen mislabeling or loss) between specimen collection and laboratory accessioning. Specific goals were to decrease preanalytic errors by at least 70% and to simultaneously decrease employee effort dedicated to resolving preanalytic errors or investigating lost specimens.
Design.— A radio-frequency identification specimen-tracking system was developed. Major features included integral radio-frequency identification labels (radio-frequency identification tags and traditional bar codes in a single printed label) printed by point-of-care printers in collection suites; dispersed radio-frequency identification readers at major transit points; and systems integration of the electronic health record, laboratory information system, and radio-frequency identification tracking system to allow for computerized physician order entry–driven label generation, specimen–transit-time tracking, interval-based alarms, and automated accessioning.
Results.— In the 6-month postimplementation period, 6 mislabeling events occurred in collection areas using the radio-frequency identification system, compared with 24 events in the 6-month preimplementation period (75% decrease; P = .001). In addition, the system led to the timely recovery of 3 lost specimens. Labeling expenses were decreased substantially in the transition from high-frequency to ultrahigh-frequency radio-frequency identification tags.
Conclusions.— Radio-frequency identification specimen tracking prevented several potential specimen-loss events, decreased specimen recovery time, and decreased specimen-labeling errors. Increases in labeling/tracking expenses for the system were more than offset by time savings and loss avoidance though error mitigation.

Saturday, June 22, 2019

Micropapillary adenocarcinoma of lung: Morphological criteria and diagnostic reproducibility among pulmonary pathologists

 2019 Apr 24;41:43-50. doi: 10.1016/j.anndiagpath.2019.04.008. [Epub ahead of print]

Micropapillary adenocarcinoma of lung: Morphological criteria and diagnostic reproducibility among pulmonary pathologists.

Author information

1
Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, USA.
2
Health Sciences Research Department, Mayo Clinic, Rochester, MN, USA.
3
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
4
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
5
Department of Pathology, The University of Mississippi Medical Center, MS, USA.
6
Department of Pathology, Harvard Medical School, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
7
Department of Anatomic Pathology, The Mount Sinai Hospital, New York, NY, USA.
8
Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, USA.
9
Kaiser Permanente, Santa Clara Medical Center and Medical Offices, Santa Clara, CA, USA.
10
Department of Pathology, Mayo Clinic, Phoenix, AZ, USA.
11
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
12
Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, USA; Health Sciences Research Department, Mayo Clinic, Rochester, MN, USA.
13
Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, USA. Electronic address: JaeRo@houstonmethodist.org.

Abstract

CONTEXT:

Invasive micropapillary adenocarcinoma (MPC) is an aggressive variant of lung adenocarcinoma, frequently manifesting with advanced stage lymph node metastasis and decreased survival.

OBJECTIVE:

Identification of this morphology is important, as it is strongly correlated with poor prognosis regardless of the amount of MPC component. To date, no study has investigated the morphological criteria used to objectively diagnose it.

DESIGN:

Herein, we selected 30 cases of potential MPC of lung, and distributed 2 digital images per case among 15 pulmonary pathology experts. Reviewers were requested to diagnostically interpret, assign the percentage of MPC component, and record the morphological features they identified. The noted features included: columnar cells, elongated slender cell nests, extensive stromal retraction, lumen formation with internal epithelial tufting, epithelial signet ring-like forms, intracytoplasmic vacuolization, multiple nests in the same alveolar space, back-to-back lacunar spaces, epithelial nest anastomosis, marked pleomorphism, peripherally oriented nuclei, randomly distributed nuclei, small/medium/large tumor nest size, fibrovascular cores, and spread through air-spaces (STAS).

RESULTS:

Cluster analysis revealed three subgroups with the following diagnoses: "MPC", "combined papillary and MPC", and "others". The subgroups correlated with the reported median percentage of MPC. Intracytoplasmic vacuolization, epithelial nest anastomosis/confluence, multiple nests in the same alveolar space, and small/medium tumor nest size were the most common criteria identified in the cases diagnosed as MPC. Peripherally oriented nuclei and epithelial signet ring-like forms were frequently identified in both the "MPC" and "combined papillary and MPC" groups.

CONCLUSIONS:

Our study provides objective diagnostic criteria to diagnose MPC of lung.

Sunday, June 2, 2019

I am a practicing pathologist and currently serve on the College of American Pathologists Board of Governors. I am a Candidate for the College of American Pathologists' President-Elect, 2019-2021 term. My vision is here.

I am a practicing pathologist and currently serve on the College of American Pathologists Board of Governors.  I am a Candidate for the College of American Pathologists' President-Elect, 2019-2021 term.  My vision is here.

Membership Growth. Pathologist Payment.

A pair of glasses were left on the floor at a museum and everyone mistook it for art HT:KL

A pair of glasses were left on the floor at a museum and everyone mistook it for art

The Trust Revolution How the Digitization of Trust Will Revolutionize Business and Government - Todd Henderson and Salen Churi

The Trust Revolution

How the Digitization of Trust Will Revolutionize Business and Government



M.Todd HendersonUniversity of Chicago , Salen ChuriTrust Ventures


The Trust Revolution



Book description

While conventional wisdom dictates that people's trust – in the government, in corporations, in each other - is at a historic low, the rise of the internet is offering new ways to rehabilitate and strengthen trust. Uber is probably the best example of a new company that, on the surface, allows individuals with smartphones to get rides with strangers, but at a deeper level is in the business of trust. In The Trust Revolution, M. Todd Henderson and Salen Churi trace the history of innovation and trust, linking companies such as Uber with medieval guilds, early corporations, self-regulatory organizations, and New-Deal era administrative agencies. This book should be read by anyone who wants to understand how trust - and its means of creation - has the potential not only to expand opportunities for human cooperation, but also to reduce the size and scope of government and corporate control over our lives.

Monday, May 27, 2019

Texas A&M Singing Cadets - God Bless the USA #MemorialDay



Texas A&M Singing Cadets - God Bless the USA

"National forgetting doesn’t bode well for the future." #MemorialDay

Remember the Fallen, and Their Cause

Memorial Day pays tribute to those who gave their lives for their country—but we should know more about why.
May 24, 2019



"Of the 16 million Americans who fought in World War II, just under 500,000 remained alive in 2018. World War II veterans are dying at a rate of 350 per day. The last surviving World War II vet will likely die sometime in 2044.
Before that happens, we owe these soldiers a display of national gratitude—but a holiday commemorating World War II will be even more important when they’re gone. Tomorrow’s children will be born into a country that has forgotten the legacy of the war, and not just because those who fought it are no longer with us. The idea of the “Greatest Generation” has gone from honorific to punchline. Today, we’re quick to criticize America’s wartime decisions, whether the firebombing of Dresden or the decision to drop atomic bombs on Hiroshima and Nagasaki. Even the photo of the sailor and nurse, once the jubilant symbol of a triumphant nation, is viewed by some as a depiction of sexual assault.
National forgetting doesn’t bode well for the future. Today, too many Americans deride any opposing viewpoint as beyond the pale. Political opponents are casually smeared as “Nazis.” We fail to take seriously the evils of twentieth-century fascism, in part because we no longer acknowledge the moral rectitude of the Allies. We’re less equipped now to defeat fascism in its resurgent cultural manifestations.

Those living in the Eastern European countries that bore the brunt of Hitler’s murderous campaigns understand this well. Their countries still mark the end of World War II with pageantry and parades. Nothing less than the fate of the world hung in the balance during those six long years. Had things gone the other way, humanity would have taken an unimaginably dark turn. That is well worth celebrating, now and forever."

Sunday, May 26, 2019

"The word ‘monster’ comes from the Latin monere, to warn. We need monsters..."

Susan Sontag was a monster


"This is how I see her monstrosity: residing not in whether she was or was not likeable, but in her relentlessness, and her refusal to pander. The word ‘monster’ comes from the Latin monere, to warn. We need monsters like Sontag because they aren’t afraid to speak a certain kind of truth: cutting through cant, received opinion, nationalist rote, the efforts of alt-Right bot farms. We need critics who insist on hierarchies of thought and output, instead of buying into marketing hype that makes everyone really, really good, critics who don’t lunge straight for content, for what a book is ‘about’ or what it ‘says’, but who stop to consider form, and style – which, as Sontag shows us, are inextricably bound up in content. We need critics to keep us on our toes, to question authority, sweeping claims, totalising world views. We need Sontag to help us think for ourselves, and be unafraid to speak our minds. And we need her for these things now, more than ever. Maintaining a lively critical capability isn’t just about snark. It’s how we’re going to make it out of these dark days of nationalism and populism with our democracy intact."

Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group

 2018 Jan;142(1):89-108. doi: 10.5858/arpa.2017-0124-RA. Epub 2017 Jul 7.

Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.

Author information

1
From the Department of Pathology, University of Chicago Medical Center, Chicago, Illinois (Drs Husain and Krausz); the Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, Arizona (Dr Colby, emeritus); the Department of Pathology, University of Texas, MD Anderson Cancer Center, Houston (Dr Ordóñez); the Department of Pathology, University of Texas Medical Branch, Galveston (Dr Allen); the Department of Cellular Pathology, University Hospital of Wales and Cardiff University, Cardiff, South Glamorgan, Wales (Dr Attanoos); the Department of Pathology, Mount Sinai Medical Center, New York, New York (Dr Beasley); the Department of Pathology, University of Vermont College of Medicine, Burlington (Dr Butnor); the Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (Dr Chirieac); the Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada (Dr Churg); the Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Dr Dacic); Centre National Référent MESOPATH Departement de Biopathologie, Lyon Cedex, France (Dr Galateau-Sallé); the Department of Pathology, University Hospital of Wales, Penarth, South Glamorgan, Wales (Dr Gibbs); the Department of Pathology, PhenoPath Laboratories, Seattle, Washington (Dr Gown); the Department of Pathology & Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, (Dr Litzky); the Department of Pathology & Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California (Drs Marchevsky and Walts); the Department of Histopathology, Royal Brompton & Harefield National Health Service Foundation Trust and the National Heart and Lung Institute, Imperial College, Chelsea, London, England (Dr Nicholson); the Department of Pathology, Duke University Medical Center, Durham, North Carolina (Dr Roggli); the Department of Pathology, University of Pittsburgh, and the VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania (Dr Sharma); the Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (Dr Travis); and the Department of Pathology, University of Virginia Medical Center, Charlottesville (Dr Wick).

Abstract

CONTEXT:

- Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose.

OBJECTIVE:

- To provide updated, practical guidelines for the pathologic diagnosis of MM.

DATA SOURCES:

- Pathologists involved in the International Mesothelioma Interest Group and others with an interest and expertise in the field contributed to this update. Reference material included up-to-date, peer-reviewed publications and textbooks.

CONCLUSIONS:

- There was discussion and consensus opinion regarding guidelines for (1) distinguishing benign from malignant mesothelial proliferations (both epithelioid and spindle cell lesions), (2) cytologic diagnosis of MM, (3) recognition of the key histologic features of pleural and peritoneal MM, (4) use of histochemical and immunohistochemical stains in the diagnosis and differential diagnosis of MM, (5) differentiating epithelioid MM from various carcinomas (lung, breast, ovarian, and colonic adenocarcinomas, and squamous cell and renal cell carcinomas), (6) diagnosis of sarcomatoid MM, (7) use of molecular markers in the diagnosis of MM, (8) electron microscopy in the diagnosis of MM, and (9) some caveats and pitfalls in the diagnosis of MM. Immunohistochemical panels are integral to the diagnosis of MM, but the exact makeup of panels employed is dependent on the differential diagnosis and on the antibodies available in a given laboratory. Depending on the morphology, immunohistochemical panels should contain both positive and negative markers for mesothelial differentiation and for lesions considered in the differential diagnosis. Immunohistochemical markers should have either sensitivity or specificity greater than 80% for the lesions in question. Interpretation of positivity generally should take into account the localization of the stain (eg, nuclear versus cytoplasmic) and the percentage of cells staining (>10% is suggested for cytoplasmic and membranous markers). Selected molecular markers are now being used to distinguish benign from malignant mesothelial proliferations. These guidelines are meant to be a practical diagnostic reference for the pathologist; however, some new pathologic predictors of prognosis and response to therapy are also included.

Andy Caldwell - Invierno

Andy Caldwell - Invierno

0.2086 of a second

PAGENAUD HOLDS OFF ROSSI TO WIN INDY 500

By INDYCAR | Published: May 26, 2019



INDIANAPOLIS – Simon Pagenaud swept the month of May at Indianapolis Motor Speedway and extended Team Penske’s Indianapolis 500 legacy in thrilling fashion, holding off Alexander Rossi to win the biggest race of them all, the 103rd Indianapolis 500 presented by Gainbridge on Sunday.
Pagenaud pushed the No. 22 Menards Team Penske Chevrolet across the finish line by 0.2086 of a second ahead of Rossi, the 2016 Indy 500 winner. It was Pagenaud’s first win at “The Greatest Spectacle in Racing” and extended Team Penske’s record for Indianapolis 500 victories to 18.

HT:MC

#MemorialDay "It’s a day for remembering, and honoring, the men and women who have died while serving their country in the U.S. armed forces."

OUR VIEW: Memorial Day a time to contemplate, remember


"It’s a day for remembering, and honoring, the men and women who have died while serving their country in the U.S. armed forces.
The latest compilation pegs that number at nearly 1.355 million since 1775 — roughly half of them combat deaths — and it includes some pretty esoteric conflicts that only history buffs would recognize."

Thursday, May 23, 2019

Burden or Opportunity? Parent Experiences When Approached for Research in a Pediatric Intensive Care Unit

 2019 May;41(3):2-12. doi: 10.1002/eahr.500014.

Burden or Opportunity? Parent Experiences When Approached for Research in a Pediatric Intensive Care Unit.

Author information

1
Assistant professor of pediatrics at Northwestern University Feinberg School of Medicine and an adjunct professor of law at the Northwestern University Pritzker School of Law.
2
Research assistant at the Ann & Robert H. Lurie Children's Hospital of Chicago.
3
Medical student and research assistant at Northwestern University Feinberg School of Medicine.
4
Senior statistician at the Ann & Robert H. Lurie Children's Hospital of Chicago.
5
Professor and the vice chair of the Department of Pediatrics at Northwestern University Feinberg School of Medicine and the senior vice president of community health transformation at the Ann & Robert H. Lurie Children's Hospital of Chicago.

Abstract

Despite an ongoing need for pediatric research, low study enrollment may impede study completion, particularly in critical care. We conducted a prospective cross-sectional survey and chart review study to assess parent experiences with research in a pediatric intensive care unit (PICU). Of the 80 parents who completed the study survey, 54% were approached to participate in a research study in the PICU, and 93% agreed to participate. Motivators included altruism, low burden, low risk, and research that would benefit the child. Barriers included risks to the child, the child's being too sick to participate, feeling overwhelmed, not having enough time to participate, the research's being burdensome, and the research's not being explained well. PICU parents had mostly favorable attitudes toward research participation. Compared with non-Hispanic survey respondents, respondents of Hispanic ethnicity less often reported having been approached for research, which further evidences the need to track research recruitment processes to help avoid underinclusion of members of minority populations.

Keep Calm and Tweet On: Legal and Ethical Considerations for Pathologists Using Social Media

 2019 Jan;143(1):75-80. doi: 10.5858/arpa.2018-0313-SA. Epub 2018 Aug 22.

Keep Calm and Tweet On: Legal and Ethical Considerations for Pathologists Using Social Media.

Author information

1
From the Department of Pathology, University of Arkansas for Medical Sciences, Little Rock (Dr Gardner); and Department of Pathology, University of Mississippi Medical Center, Jackson (Dr Allen).

Abstract

Recent privacy breaches by a major social media company have again raised questions from some pathologists regarding the legality and ethics of sharing pathology images on social media. The authors examined ethical principles as well as historic and legal precedents relevant to pathology medical photography. Taking and sharing photographs of pathology specimens is embedded into the culture of the specialty of pathology and has been for more than a century. In general, the pathologist who takes the photograph of a gross or microscopic specimen owns the copyright to that photograph. Patient consent is not legally or ethically required to take or use deidentified photographs of pathology specimens. Current US privacy laws (Health Insurance Portability and Accountability Act [HIPAA] of 1996) permit public sharing of deidentified pathology photographs without specific patient consent, even on social media. There is no case law of action taken against pathologists for sharing deidentified pathology images on social media or elsewhere. If there is any legal risk for pathologists or risk of patient harm in sharing pathology photographs, it is very small. The benefits of professional social media use for pathologists, patients, and society are numerous and well documented in the literature.