http://www.ncbi.nlm.nih.gov/pubmed/21274504
Mol Med. 2011 Jan 25. doi: 10.2119/molmed.2011.00021. [Epub ahead of print]
HDAC inhibition as a novel treatment for diabetes mellitus.
Christensen DP, Dahllöf M, Lundh M, Rasmussen DN, Nielsen MD, Billestrup N, Grunnet LG, Mandrup-Poulsen T.
Center for Medical Research Methodology, Dept. of Biomedical Sciences, University of Copenhagen, Denmark.
Abstract
Both common forms of diabetes have an inflammatory pathogenesis in which immune and metabolic factors converge on IL-1β as a key mediator of insulin resistance and beta-cell failure. In addition to improving insulin resistance and preventing β-cell inflammatory damage there is evidence of genetic association between diabetes and histone deacetylases (HDACs), and HDAC inhibitors promote b-cell development, proliferation, differentiation and function and positively impact on late diabetic microvascular complications. Here we review this evidence and propose that there is a strong rationale for preclinical studies and clinical trials with the aim of testing the utility of HDACi as a novel therapy for diabetes.
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