http://www.ncbi.nlm.nih.gov/pubmed/21406513
Eur Respir J. 2011 Mar 15. [Epub ahead of print]
Accuracy of Cell Typing in Non-Small Cell Lung Cancer by EBUS/EUS - FNA Cytology Samples.
Wallace WA, Rassl DM.
NHS Lothian and Division of Pathology, College of Medicine and Veterinary Medicine, Edinburgh University UK.
Abstract
Endoscopic ultrasound guided transbronchial or trans-oesophageal lymph node aspiration is increasingly used as a method of diagnosing non-small cell carcinoma. Data validating the accuracy of cell typing of non-small cell carcinoma using these cytology samples has not been assessed. Twenty three samples were identified in Edinburgh and a further twenty five in Cambridge with matching histological samples. The morphological cell type as assessed on the cytology preparations and cell blocks was recorded and immunohistochemical staining was performed where possible as an adjunct. The final cell type as assessed by morphology with or without immunohistochemistry was correlated with that reported in the paired histology samples. Cell blocks with tumour were available in 39/48 cases. The accuracy of cell typing when no cell block was available was 4/9, This increased to 25/39 when a cell block was available rising to 33/39 with the addition of immunohistochemistry. The overall accuracy of classification was 37/48. Accurate cell typing of non-small cell carcinomas can be performed using endoscopically derived fine needle aspirates. The importance of obtaining sufficient material for the production of cell blocks is critical in allowing optimal assessment.
No comments:
Post a Comment