Interstitial Pneumonia Associated With Ulcerative Colitis

http://www.ncbi.nlm.nih.gov/pubmed/22847639

J Thorac Imaging. 2012 Jul 27. [Epub ahead of print]

Interstitial Pneumonia Associated With Ulcerative Colitis: High-resolution Computed Tomography and Pathologic Findings.

Ikehara N, Fujimoto K, Sadohara J, Iwamoto R, Tajiri M, Okamoto M, Fukuoka J.

Source

*Department of Radiology ‡Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine †Center for Diagnostic Imaging, Kurume University Hospital, Kurume §Department of Surgical Pathology, Toyama University Hospital, Toyama, Japan.

Abstract

Pulmonary parenchymal manifestations associated with ulcerative colitis (UC) include various conditions such as opportunistic infections, interstitial pneumonia, organizing pneumonia, and adverse drug reactions. We present a case of interstitial pneumonia associated with UC in a 61-year-old nonsmoking woman. High-resolution computed tomography demonstrated multifocal ill-defined areas of consolidation and ground-glass attenuation with or without traction bronchiectasis, predominantly in peripheral lung parenchyma. Lung biopsy showed that the closest pathologic pattern in the areas of abnormality was cellular and fibrotic nonspecific interstitial pneumonia. We also discuss the evaluation and treatment of pulmonary disease possibly related to UC in the clinical course of this patient.