http://www.ncbi.nlm.nih.gov/pubmed/23639645

Gastroenterol Clin North Am. 2013 Jun;42(2):359-69. doi: 10.1016/j.gtc.2013.01.011. Epub 2013 Mar 1.

Modern oncological approaches to gastric adenocarcinoma.

Wadhwa R, Taketa T, Sudo K, Blum MA, Ajani JA.

Source

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Abstract

Gastric cancer (GC) is a major health burden throughout the world, especially in certain endemic regions. GC is commonly diagnosed at an advanced stage because of the lack of early detection strategies and is usually associated with a dismal outcome. For patients with localized GC (LGC), surgery is the best cure: cure rates are highly associated with the surgical pathology stage. Adjunctive therapies improve the cure rates by about an additional 10%. Therefore, a multimodality approach is highly recommended for all patients with LGC. This article highlights some of the therapeutic advances made against GC and features important ongoing trials.