Psychiatry Clin Neurosci. 2014 Jan 9. doi: 10.1111/pcn.12135. [Epub ahead of print]

Predicting 10-year quality-of-life outcomes of patients with schizophrenia and schizoaffective disorders.

Ritsner MS, Lisker A, Grinshpoon A.

Author information

• Sha'ar Menashe Mental Health Center, Israel Affiliated to the Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.

Abstract

AIMS:

This study aimed to determine predictors for 10-year good versus poor perceived general quality of life (QOL) outcomes from baseline variables in people with schizophrenia and schizoaffective disorder.

METHODS:

We compared patients with poor versus good 10-year QOL outcomes using baseline clinical, personality-related variables, demographic and background characteristics. Logistic regression analysis was used for predicting the 10-year QOL outcomes from baseline data. One-hundred-eight patients completed the Quality-of-Life Enjoyment and Life Satisfaction Questionnaire, the Positive and Negative Syndromes Scale (PANSS), the Talbieh Brief Distress Inventory, and psychosocial questionnaires at baseline and 10 years later.

RESULTS:

Logistic regression revealed six predictors of QOL outcomes: paranoid ideations (odds ratio [OR] 3.1), PANSS general psychopathology (OR 1.1), obsessiveness (OR 0.84), hostility (OR 0.4), PANSS positive scale scores (OR 0.4), and general QOL index (OR 0.4). This model classified 80.6% of the sample with good sensitivity (87% correctly identified 'poor outcome'), and specificity (71% correctly identified 'good outcome').

CONCLUSION:

This study provides a pattern of baseline predictors for long-term QOL outcomes. Identified predictors are factors that can potentially be ameliorated, and thereby enhance the QOL of people with schizophrenia and schizoaffective disorder.