"The bottom line is, obese and overweight patients are exceedingly unlikely to be successful with weight-loss attempts that utilize mainstream diet and exercise products."

There are real, and difficult, biological reasons why it’s hard to lose weight

"The bottom line is, obese and overweight patients are exceedingly unlikely to be successful with weight-loss attempts that utilize mainstream diet and exercise products. These products are generated with the intent to sell, and the marketing efforts behind them are comparable to the well-known distractions generated by the Wizard of Oz. The reality is, the body fights against calorie restriction and new exercise. This resistance from the body can be lessened using medical procedures, by new medications or by increasing one’s exercise capacity to a critical point."