Saturday, October 22, 2016

And yet: Study finds ten minutes of children exercising can keep obesity at bay

Study finds ten minutes of children exercising can keep obesity at bay


"Children engaging in ten minutes of high-intensity physical activity every day had 26-30 per cent less central body fat than children who did not engage in high-intensity physical activity."


Read more at http://www.bathchronicle.co.uk/study-finds-ten-minutes-of-children-exercising-can-keep-obesity-at-bay/story-29831455-detail/story.html#3dSDorcdBDkbQWYX.99

Drug use in business bathrooms

 2016 Oct 18;39:69-77. doi: 10.1016/j.drugpo.2016.08.014. [Epub ahead of print]

Drug use in business bathrooms: An exploratory study of manager encounters in New York City.

Author information

  • 1National Development & Research Institute, Institute for Special Populations Research, 71 W. 23rd St., 4th Fl., New York, NY 10100, United States of America; Center for Drug Use and HIV/HCV Research, Rory Meyers College of Nursing, New York University, 433 First Avenue, New York, NY 10100, United States of America. Electronic address: wolfson-stofko@ndri.org.
  • 2National Development & Research Institute, Institute for Special Populations Research, 71 W. 23rd St., 4th Fl., New York, NY 10100, United States of America; Center for Drug Use and HIV/HCV Research, Rory Meyers College of Nursing, New York University, 433 First Avenue, New York, NY 10100, United States of America.
  • 3John Jay College of Criminal Justice, City University of New York, Department of Law, Police Science and Criminal Justice Administration, and Department of Anthropology, 524 W. 59th St., New York, NY 10019, United States of America; Center for Drug Use and HIV/HCV Research, Rory Meyers College of Nursing, New York University, 433 First Avenue, New York, NY 10100, United States of America.

Abstract

BACKGROUND:

Though public bathroom drug injection has been documented from the perspective of people who inject drugs, no research has explored the experiences of the business managers who oversee their business bathrooms and respond to drug use. These managers, by default, are first-responders in the event of a drug overdose and thus of intrinsic interest during the current epidemic of opioid-related overdoses in the United States. This exploratory study assists in elucidating the experiences that New York City business managers have with people who inject drugs, their paraphernalia, and their overdoses.

METHODS:

A survey instrument was designed to collect data on manager encounters with drug use occurring in their business bathrooms. Recruitment was guided by convenience and purposive approaches.

RESULTS:

More than half of managers interviewed (58%, n=50/86) encountered drug use in their business bathrooms, more than a third (34%) of these managers also found syringes, and the vast majority (90%) of managers had received no overdose recognition or naloxone training. Seven managers encountered unresponsive individuals who required emergency assistance.

CONCLUSION:

The results from this study underscore the need for additional research on the experiences that community stakeholders have with public injection as well as educational outreach efforts among business managers. This research also suggests that there is need for a national dialogue about potential interventions, including expanded overdose recognition and naloxone training and supervised injection facilities (SIF)/drug consumption rooms (DCR), that could reduce public injection and its associated health risks.

Why medical ethics matters: "Scratching the surface of the history of any real human-skin book usually reveals a doctor was the one wielding the knife."

A Book by Its Cover

The strange history of books bound in human skin.
WEDNESDAY, OCTOBER 19, 2016

"Scratching the surface of the history of any real human-skin book usually reveals a doctor was the one wielding the knife. At a time when physicians were climbing social classes and enjoying the trappings of their new wealth and status—including becoming collectors of fine art and books—at least a few chose to preserve the hides of deceased indigent patients to bind copies of their own work or of those that they admired, like anatomist Andreas Vesalius. (Brown University’s Hay Library holds a large, beautiful anthropodermic Vesalius, in addition to three other books proved to be bound in human skin.) At the same time, public executions were one of the only legal sources for obtaining bodies for dissection. Doctors sometimes removed the skins of infamous murderers and used them to bind books about their deeds—a fact well known enough to serve as a kind of deterrent. The most infamous case is the pocket-sized book bound in the skin of William Burke, half of the Scottish duo Burke and Hare, who murdered sixteen people in order to sell their bodies to doctors for dissection. Like his unfortunate victims, Burke could not escape the anatomist’s knife in the end, and his skin book resides in Surgeons’ Hall Museum in Edinburgh. While doctors today refuse to participate in executions, citing the principle of “first do no harm,” doctors in the eighteenth and nineteenth centuries worked with their governments to ensure their access to dead bodies for anatomical learning."

Ethical, Legal, and Social Implications of Personalized Genomic Medicine Research

 2016 Nov;30(9):698-705. doi: 10.1111/bioe.12285.

Ethical, Legal, and Social Implications of Personalized Genomic Medicine Research: Current Literature and Suggestions for the Future.

Author information

  • 1scallier@gwu.edu.

Abstract

PURPOSE:

This review identifies the prominent topics in the literature pertaining to the ethical, legal, and social issues (ELSI) raised by research investigating personalized genomic medicine (PGM).

METHODS:

The abstracts of 953 articles extracted from scholarly databases and published during a 5-year period (2008-2012) were reviewed. A total of 299 articles met our research criteria and were organized thematically to assess the representation of ELSI issues for stakeholders, health specialties, journals, and empirical studies.

RESULTS:

ELSI analyses were published in both scientific and ethics journals. Investigational research comprised 45% of the literature reviewed (135 articles) and the remaining 55% (164 articles) comprised normative analyses. Traditional ELSI concerns dominated the discourse including discussions about disclosure of research results. In fact, there was a dramatic increase in the number of articles focused on the disclosure of research results and incidental findings to research participants. Few papers focused on particular disorders, the use of racial categories in research, international communities, or special populations (e.g., adolescents, elderly patients, or ethnic groups).

CONCLUSION:

Considering that strategies in personalized medicine increasingly target individuals' unique health conditions, environments, and ancestries, further analysis is needed on how ELSI scholarship can better serve the increasingly global, interdisciplinary, and diverse PGM research community.

Hindustan Times: Mistreating overweight people doubles their health risk

Show some heart, mistreating overweight people doubles their health risk


“Even if we accounted for health effects attributed to being overweight, these people still experience double the risk of allostatic load because of weight discrimination,” said Vadiveloo. The findings expose flaws in society’s approach to weight control, she said.

Friday, October 21, 2016

Rap1, a potential new target to treat obesity

Rap1, a potential new target to treat obesity


"The  have shown a new mechanism by which the brain can affect the development of obesity triggered by consuming a high-fat diet. Consuming a  results in changes in the brain that increase Rap1 activity, which in turn leads to a decreased sensitivity to leptin, and this sets the body on a path to obesity."

The Case for Using Twitter Professionally

 2016 Sep;140(9):956-7. doi: 10.5858/arpa.2016-0172-SA. Epub 2016 May 19.

Let's Have a Tweetup: The Case for Using Twitter Professionally.

Author information

  • 1From the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas (Dr Fuller); and the Department of Pathology, University of Texas Medical Branch, Galveston (Dr Allen).

Abstract

Social media use is very common and can be an effective way for professionals to discuss information and interact with colleagues. Twitter (Twitter, Inc, San Francisco, California) is a social media network where posts, termed tweets, are limited to 140 characters. Professional use of Twitter is ideal for physicians interested in both networking and education and is optimally used to facilitate in-person networking. Live-tweeting (posting real-time reactions to events) at professional meetings is also a popular and highly successful use of Twitter. Physicians report patient privacy as the top concern preventing use of social media for professional reasons, and although generally social media use is safe, it is essential to understand how to protect patient confidentially. Other social media platforms with potential for professional use include Facebook (Facebook, Inc, Menlo Park, California), Instagram (Facebook, Inc), YouTube (YouTube, LLC, San Bruno, California), and Periscope (Twitter, Inc). With Twitter and other social media options, now is the time for pathologists to increase our visibility on social media and worldwide.

The importance of the amount of physical activity on the risk of developing type 2 diabetes

The importance of the amount of physical activity on the risk of developing type 2 diabetes


Physical activity is a cornerstone of advice to both prevent and manage T2D, having been shown to lower blood glucose levels, reduce cardiovascular risk, and help reduce body fat in the large number of diabetics who are overweight or obese. Current advice for those with T2D promotes a minimum of 150 minutes of PA per week divided into 5 days of 30 minutes each. These 30 minutes per day can be completed either as a single block, or spread throughout the day, to aid compliance. It does not, however, specify when that activity should take place, and as the authors state: "The current study is the first controlled study conducted in free-living adults with T2D that has aimed to determine whether prescribed walking taken for short periods after meals confers longer-term benefits than walking on a single occasion at any time of the day."

Eradicating polio in Pakistan

 2016 Oct 12;12(1):63.

Eradicating polio in Pakistan: an analysis of the challenges and solutions to this security and health issue.

Author information

  • 1Conflict and Health Research Group, King's Centre for Global Health, King's College London, Suite 2.13 Weston Education Centre, Cutcombe Road, London, SE5 9RJ, UK. shoaib_fahad.hussain@kcl.ac.uk.
  • 2International Prevention Research Institute, Lyon, France.
  • 3University of Strathclyde Institute of Global Public Health @iPRI, Lyon, France.
  • 4Department of War Studies and Conflict and Health Research Group, King's College London, London, UK.
  • 5Conflict and Health Research Group, King's Centre for Global Health, King's College London, Suite 2.13 Weston Education Centre, Cutcombe Road, London, SE5 9RJ, UK.

Abstract

Since the launch of the Global Polio Eradication Initiative (GPEI) in 1988 the global incidence of poliomyelitis has fallen by nearly 99 %. From a situation where wild type poliovirus was endemic in 125 countries across five continents, transmission is now limited to regions of just three countries - Pakistan, Afghanistan and Nigeria. A sharp increase in Pakistan's poliomyelitis cases in 2014 prompted the International Health Regulations Emergency Committee to declare the situation a 'public health emergency of international concern'. Global polio eradication hinges on Pakistan's ability to address the religious, political and socioeconomic barriers to immunisation; including discrepancies in vaccine coverage, a poor health infrastructure, and conflict in polio-endemic regions of the country. This analysis provides an overview of the GPEI, focusing on the historical and contemporary challenges facing Pakistan's polio eradication programme and the impact of conflict and insecurity, and sheds light on strategies to combat vaccine hesitancy, engage local communities and build on recent progress towards polio eradication in Pakistan.

"...almost 1 in 6 adults — 15.9 percent — in the EU is considered obese."

EU Obesity Rankings: Malta Has The Highest Rate Of Obesity, Followed By Latvia


"The European Health Interview Survey, conducted by Eurostat, showed that almost 1 in 6 adults — 15.9 percent — in the EU is considered obese. The instance of the condition increased with factors like age and fell with higher levels of education, Eurostat data showed.
Malta emerged on top of the obesity list with 26 percent of its adults being categorized as obese. It was followed by Latvia (21.3 percent), Hungary (21.2 percent) and Estonia (20.4 percent).
Britain — expected to leave the union soon in accordance with its Brexit vote — came in fifth with 20.1 percent of its adults being obese. This was despite the fact that Eurostat figures released last week showed that the country was on top when it came to healthy eating — consuming five portions of fruit and vegetables a day, as recommended.
Romania’s rate of obesity was the lowest in the union with 9.4 percent individuals figuring in the category. Italy (10.7 percent) and the Netherlands (13.3 percent) were next."

The barriers and enablers of healthy eating among young adults ("...government intervention ...remains essential...")

 2016 Oct 20. doi: 10.1111/obr.12472. [Epub ahead of print]

The barriers and enablers of healthy eating among young adults: a missing piece of the obesity puzzle: A scoping review.

Author information

  • 1School of Life and Environmental Sciences, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
  • 2School of Life and Environmental Sciences, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia. margaret.allman-farinelli@sydney.edu.au.

Abstract

Young adults in Western countries are gaining weight faster than their parents and are more likely to gain weight than any other age cohort. Despite this, investigation into the complex young adults' food choice motives, which enable and prevent healthy eating, has not been widely investigated. A scoping review was conducted involving an extensive literature search of four major electronic databases: Medline, Embase, PsychInfo and CINAHL. Data were collected from 34 articles: study descriptions numerically analysed and key findings thematically analysed. The key barriers found included: male apathy towards diet; unhealthy diet of friends and family; expected consumption of unhealthy foods in certain situations; relative low cost of unhealthy foods; lack of time to plan, shop, prepare and cook healthy foods; lack of facilities to prepare, cook and store healthy foods; widespread presence of unhealthy foods; lack of knowledge and skills to plan, shop, prepare and cook healthy foods; lack of motivation to eat healthily (including risk-taking behaviour). The key enablers found included: female interest in a healthy diet; healthy diet of friends and family; support/encouragement of friends and family to eat healthy; desire for improved health; desire for weight management; desire for improved self-esteem; desire for attractiveness to potential partners and others; possessing autonomous motivation to eat healthy and existence and use of self-regulatory skills. This research provides evidence that can be used to tailor interventions for healthy eating and overweight and obesity in this population. However, government intervention in addressing food access, affordability, marketing and taxation remains essential to any significant change.

The Evolutionary Origin and Genetic Makeup of Domestic Horses

 2016 Oct;204(2):423-434.

The Evolutionary Origin and Genetic Makeup of Domestic Horses.

Author information

  • 1Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K, Denmark.
  • 2Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K, Denmark Laboratoire Anthropobiologie Moléculaire et d'Imagerie de Synthèse, Centre National de la Recherche Scientifique UMR 5288, Université Paul Sabatier (Toulouse III), 31000 Toulouse, France.
  • 3Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K, Denmark Biodiversité Gènes et Communautés UMR1202, Institut National de la Recherche Agronomique, F-33610 Cestas, France Biodiversité Gènes et Communautés UMR1202, Université de Bordeaux, F-33170 Talence, France.
  • 4Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K, Denmark Department of Biotechnology, Abdul Wali Khan University, Mardan, Pakistan.
  • 5Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
  • 6Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350K, Denmark Laboratoire Anthropobiologie Moléculaire et d'Imagerie de Synthèse, Centre National de la Recherche Scientifique UMR 5288, Université Paul Sabatier (Toulouse III), 31000 Toulouse, France Lorlando@snm.ku.dk.

Abstract

The horse was domesticated only 5.5 KYA, thousands of years after dogs, cattle, pigs, sheep, and goats. The horse nonetheless represents the domestic animal that most impacted human history; providing us with rapid transportation, which has considerably changed the speed and magnitude of the circulation of goods and people, as well as their cultures and diseases. By revolutionizing warfare and agriculture, horses also deeply influenced the politico-economic trajectory of human societies. Reciprocally, human activities have circled back on the recent evolution of the horse, by creating hundreds of domestic breeds through selective programs, while leading all wild populations to near extinction. Despite being tightly associated with humans, several aspects in the evolution of the domestic horse remain controversial. Here, we review recent advances in comparative genomics and paleogenomics that helped advance our understanding of the genetic foundation of domestic horses.

MicroRNA, epigenetic machinery and lung cancer

 2011 May;2(2):35-44. doi: 10.1111/j.1759-7714.2011.00043.x.

MicroRNA, epigenetic machinery and lung cancer.

Author information

  • 1Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, USA.

Abstract

Lung cancer is the leading cause of cancer deaths worldwide and over 80% of lung cancer patients are classified as having non-small celllung cancer. Although there have been technological advancements in the early detection and standard treatment of lung cancer, it is often diagnosed at an advanced stage and is chemoresistant to most available drugs. A number of studies have demonstrated that microRNA is able to modulate various tumorigenic processes, including progression and metastasis, in various mechanisms. In this review we examine the most recent achievements in microRNA and lung cancer treatment and summarize the research progress on the reciprocal regulation between microRNA and epigenetic modifications, as both have been intensively studied in lung cancer. Epigenetic modifications on the human genome regulate gene and microRNA expression at the transcriptional level; inversely, microRNA can also transcriptionally cleave and/or translationally repress the expression of several key enzymes involved in epigenetic processes such as DNA methylation and histone modification. Better understanding of reciprocal regulation between microRNA and epigenetic modifications will underlie the development of novel microRNA orientated diagnostic and therapeutic strategies relating to lung cancer in the near future.

News media coverage of U.S. Ebola policies

 2016 Sep 21;93:115-120. doi: 10.1016/j.ypmed.2016.09.016. [Epub ahead of print]

News media coverage of U.S. Ebola policies: Implications for communication during future infectious disease threats.

Author information

  • 1Johns Hopkins Bloomberg School of Public Health, Department of Health Policy and Management, 624 N. Broadway, Baltimore, MD 21205, United States; UPMC Center for Health Security, 621 E Pratt St. Suite 210, Baltimore, MD 21202, United States. Electronic address: tksell@upmc.edu.
  • 2Johns Hopkins Bloomberg School of Public Health, Department of Health Policy and Management, 624 N. Broadway, Baltimore, MD 21205, United States; UPMC Center for Health Security, 621 E Pratt St. Suite 210, Baltimore, MD 21202, United States.
  • 3Johns Hopkins Bloomberg School of Public Health, Department of Health Policy and Management, 624 N. Broadway, Baltimore, MD 21205, United States.
  • 4Johns Hopkins Bloomberg School of Public Health, Department of Health, Behavior and Society, 624 N. Broadway, Baltimore, MD 21205, United States.
  • 5United States Environmental Protection Agency, 1200 Pennsylvania Avenue, N.W. Washington, District of Columbia 20460, United States.

Abstract

The Ebola outbreak of 2014-2015 raised concerns about the disease's potential spread in the U.S. and received significant news media coverage. Prior research has shown that news media coverage of policy options can influence public opinion regarding those policies, as well as public attitudes toward the broader social issues and target populations addressed by such policies. To assess news media coverage of Ebola policies, the content of U.S.-focused news stories (n=1262) published between July 1 and November 30, 2014 from 12 news sources was analyzed for 13 policy-related messages. Eight-two percent of news stories mentioned one or more policy-related messages. The most frequently appearing policy-related messages overall were those about isolation (47%) and quarantine (40%). The least frequently mentioned policy-related message described dividing potentially exposed persons into distinct groups based on their level of Ebola risk in order to set different levels of restrictions (5%). Message frequency differed depending on whether news sources were located in an area that experienced an Ebola case or controversy, by news sources' political ideological perspective, and by type of news source (print and television). All policy-related messages showed significant increases in frequency after the first case of Ebola was diagnosed in the U.S. on September 30, 2014, with the exception of messages related to isolation, which showed a significant decrease. Results offer insight into how the news media covers policies to manage emerging disease threats.

Report suggests three-quarters of Canadian Forces personnel are overweight, obese

Report suggests three-quarters of Canadian Forces personnel are overweight, obese


 

The HLIS also examined issues like excessive drinking and mental health problems.
The report states that while there’s been little change in the percentage of personnel engaged in harmful drinking over the past few years, “a substantial proportion of personnel are still engaged in high risk/harmful drinking behaviours including binge drinking.”


Thursday, October 20, 2016

I am running for a second term on the College of American Pathologists Board of Governors.

My vision is here.

This is very bad: "...a third of millennials say they believe more people were killed under George W. Bush than Joseph Stalin."

Poll: Millennials desperately need to bone up on the history of communism


"Furthermore, almost half of Americans between the ages of 16 and 20 said they would vote for a socialist, while 21% would go so far as to back a communist.
Capitalism, on the other hand, is viewed favorably by 64% of those over the age of 65, compared with only 42% of millennials.
In fact, more than half of millennials say the economic system works against them, while four out of 10 call for a “complete change” to ensure that the highest earners pay their fair share."
.....................

"There’s a lack of historical perspective, according to the foundation, that the survey showed among a big chunk of the younger generation. For instance, a third of millennials say they believe more people were killed under George W. Bush than Joseph Stalin."


HT:AP

The Effect of Widowhood on Mental Health

 2016 Oct 16. doi: 10.1002/hec.3443. [Epub ahead of print]

The Effect of Widowhood on Mental Health - an Analysis of Anticipation Patterns Surrounding the Death of a Spouse.

Author information

  • 1Department of Economics, SFB 884 "Political Economy of Reforms" University of Mannheim, Germany. bettina.siflinger@uni-mannheim.de.

Abstract

This study explores the effects of widowhood on mental health by taking into account the anticipation and adaptation to the partner's death. The empirical analysis uses representative panel data from the USA that are linked to administrative death records of the National Death Index. I estimate static and dynamic specifications of the panel probit model in which unobserved heterogeneity is modeled with correlated random effects. I find strong anticipation effects of the partner's death on the probability of depression, implying that the partner's death event cannot be assumed to be exogenous in econometric models. In the absence of any anticipation effects, the partner's death has long-lasting mental health consequences, leading to a significantly slower adaptation to widowhood. The results suggest that both anticipation effects and adaptation effects can be attributed to a caregiver burden and to the cause of death. The findings of this study have important implications for designing adequate social policies for the elderly US population that alleviate the negative consequences of bereavement.

Study: Adolescent body mass index predicts diabetes mellitus mortality in midlife

Teen Overweight, Obesity Predicts Diabetes Mortality


HealthDay News — Adolescent body mass index (BMI) predicts diabetes mellitus (DM) mortality in midlife, according to a study published online in Diabetes Care.

Saturday, October 15, 2016

Solving surprise medical bills. Good overview by Brookings Institution (but does not address the common situation where MDs ask but cannot gain access to networks)

Solving surprise medical bills

5) Encourage hospitals to increase network participation by key physician specialists.
"Regulators could question whether health plan subscribers have adequate access at hospitals that lack sufficient network participation by key hospital-based specialists. This approach needs to be taken with caution however, because hospitals might have to make large financial commitments to such specialists and pass this on to insurers in higher rates for hospitals, costs ultimately borne by consumers through higher premiums. To temper this problem, regulators could use antitrust authority more actively to determine whether market power is being used inappropriately when most hospital specialists refuse to join networks."








Mark Hall, Paul Ginsburg, Steven M. Lieberman, Loren Adler, Caitlin Brandt, and Margaret Darling

Immunotherapy for malignant mesothelioma: reality check

 2016 Oct 6:1-10. [Epub ahead of print]

Immunotherapy for malignant mesothelioma: reality check.

Thapa B1,2, Watkins DN3, John T2,4,5.

Author information

  • 1a Department of Medicine, Austin Health , University of Melbourne , Melbourne , Australia.
  • 2b Cancer Imuunobiology Lab , Olivia Newton-John Cancer Research Institute , Melbourne , Australia.
  • 3c The Kinghorn Cancer Center , Garvan Institute of Medical Research , Darlinghurst , Australia.
  • 4d Department of Medical Oncology, Austin Health , Olivia-Newton John Cancer and Wellness Centre , Melbourne , Australia.
  • 5e School of Cancer Medicine , La Trobe University , Melbourne , Australia.

Abstract

INTRODUCTION:

Initial data of immune based therapy showed promise for improving malignant mesothelioma (MM) treatment. However, the results of such treatments have neither been predictable nor consistent and recent clinical studies of immune checkpoint inhibitors in MM have dampened initial enthusiasm. Areas covered: We comprehensively discuss the basis, modalities and updated results of immunotherapy in MM. An online search was conducted for relevant literature and abstracts of recent meetings. Expert commentary: Although initial studies have demonstrated proof of principle that manipulating the immune checkpoint axis holds promise in MM, results of some recent large studies using checkpoint inhibitors have been disappointing. This is not surprising given the low mutational load in MM and suggests that single agent immunotherapy has limited benefit in this disease. We believe that in order to demonstrate durable survival benefits, they will need to be used in combination approaches with other immunotherapies, vaccines or chemotherapy.

Where your can of coke costs more

Where your can of coke costs more

Governments hope soda taxes may speed a drop in sugary drink consumption

Justin Morton