Child-to-parent violence (CPV) includes acts committed by a child to intentionally cause physical, psychological, or financial pain to a parent. Available data indicate increasing rates of CPV in Spain, which have been attributed to a tendency toward more permissive parenting styles and changes in the power cycles within the families. The primary aim of this study was to assess the predictive role of some behavioral and emotional characteristics of adolescents who perpetrate CPV. A total of 1,072 adolescents (601 girls) filled out measures of CPV, proactive and reactive aggression, depressive symptoms, and substance abuse at Time 1, and measures of CPV 6 months later. The results showed that CPV was predicted by proactive, but not by reactive, aggression. This finding supports an instrumental role for CPV, which should be understood in the context of permissibility and lack of limits within the family. Depression and substance abuse also predicted the increase of CPV over time. Moreover, there were no sex differences in the prevalence of physical CPV, but verbal CPV was more predominant among girls. Although there were sex differences in some of the risk factors for CPV, the predictive model linking these risks to CPV was similar for boys and girls. Findings of this study suggest a psychological profile that combines internalizing problems and an instrumental use of violence in adolescents who perpetrate CPV. These characteristics are important for interventions.