From Memorial Sloan-Kettering: Bringing the genomic landscape of small-cell lung cancer into focus

http://www.ncbi.nlm.nih.gov/pubmed/23011222

Nat Genet. 2012 Oct;44(10):1074-5. doi: 10.1038/ng.2415.

Bringing the genomic landscape of small-cell lung cancer into focus.

Pietanza MC, Ladanyi M.

Source

Department of Medicine (Thoracic Oncology Service) Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

Abstract

Genomic characterization efforts in small-cell lung cancer have been complicated by the paucity of high-quality surgical resection specimens for this aggressive lung cancer subtype that is usually diagnosed at unresectable stages in small biopsies or cytology specimens. Now, two papers report genomic analyses of small-cell lung cancer, highlighting subsets of tumors driven by amplification of FGFR1, SOX2 or MYC family members or by a MYCL1 fusion oncogene, among many other recurrent alterations.