Hum Vaccin Immunother. 2012 Jun 1;8(6). [Epub ahead of print]
Insulin-specific vaccination for type 1 diabetes: a step closer?
Source
The Walter and Eliza Hall Institute of Medical Research; Parkville, Victoria Australia.
Abstract
Vaccination against self-antigens to avert pathological immunity to self - 'negative vaccination' - is the Holy Grail of autoimmune disease therapy. This approach depends on deletion or inactivation of pathogenic T cells, or induction of protective, 'regulatory' T cells. While effective in inbred rodent models, it is yet to be translated to humans. Reasons for this include its application only in end-stage disease, ignorance about antigen form, route of delivery and dose-schedule required for a bio-response, lack of meaningful and measurable bio-response markers, co-activation of pathogenic immunity and genetic heterogeneity.
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