J Aging Res. 2012;2012:676042. Epub 2012 Apr 26.
New Strategies to Fight against Sarcopenia at Old Age.
Source
INRA, UMR 1019, Human Nutrition Unit, Research Center of Human Nutrition (CRNH Auvergne), 63000 Clermont-Ferrand, France.
"Aging is associated with a progressive loss of muscle mass and strength, a process called sarcopenia. The most evident metabolic explanation for muscle decline in elderly people is an imbalance between protein synthesis and breakdown rates, but other causes, such as neurodegenerative processes, reduction in anabolic hormone production or sensitivity (e.g., insulin, growth, and sex hormones) and in capacity to respond to anabolic stimuli (e.g., amino acids, exercise), dysregulation of cytokine secretion, modifications in the response to inflammatory events, inadequate nutritional intake and sedentary lifestyle, are involved. The sequelae of sarcopenia often contribute to frailty, decreased independence, and subsequently increased health care costs."
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