Eur Respir J. 2012 Jul 26. [Epub ahead of print]
Quality of life and healthcare utilisation in cystic fibrosis: A multicentre UK study.
Source
School of Health Sciences, University of Ulster, Newtownabbey, Northern Ireland, BT37 0QB.
Abstract
What is the health status and healthcare utilisation associated with pulmonary exacerbations (PEx) in cystic fibrosis (CF) and chronic Pseudomonas aeruginosa infection?Patients with CF from 5 UK CF centres attended two visits, 8-12 weeks apart. They were classified at visit 1 as being in one of the three health states: no current PEx; 'mild' (no hospitalization) and 'severe' (hospitalisation) PEx. All patients completed the CFQ-R and EQ-5D, a clinical form and performed FEV1 at visit 1 and 2. Annual healthcare utilisation data were collected.Ninety-four patients, 28.5 (8.2) years; FEV1, 58.7 (26.8)% were recruited. 60 patients had no PEx, 15 had a mild and 19 had a severe PEx at visit 1. EQ-5D and CFQ-R data showed that the worse the exacerbation, the poorer the health related quality of life. There were strong relationships between the CFQ-R and EQ-5D domain scores. The mean rate of PExs per patient per year was 3.6 (1.5 hospital, 2.2 home). The mean length of stay per hospital PEx was 9 days.As exacerbation status worsens patients experience worse health related quality of life. There is a significant healthcare burden associated with treatment of PEx and long term prophylaxis.
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