Ann Thorac Surg. 2012 Jul 24. [Epub ahead of print]
Outcomes for Lung Transplantation for Lung Cancer in the United Network for Organ Sharing Registry.
Source
Section of Thoracic Surgery, Yale University School of Public Health, New Haven, Connecticut.
Abstract
BACKGROUND:
Advanced bronchoalveolar carcinoma (BAC) carries a poor prognosis, with median survival of approximately 1 year. More extended survivals have been reported after lung transplantation for BAC; however, fewer than 50 patients have been reported. To compare outcomes of lungtransplantation for advanced BAC, we studied this population in a compulsory, prospectively maintained database.
METHODS:
The United Network for Organ Sharing (UNOS) database was queried for patients undergoing lung transplant from 1987 to 2010 for thediagnosis of BAC or cancer. Pathology reports of explanted specimens were reviewed.
RESULTS:
Twenty-nine patients underwent lung transplantation for BAC, representing 0.13% of the 21,553 lung transplants during the study period. BAC patients had better forced expiratory volume in 1 second percent predicted (60% vs 35%, p < 0.0001) and received more double-lung transplants (79% vs 54%, p = 0.006). Pure BAC was present in only 52% of the explants, whereas 41% had some degree of invasive tumor, and 7% had pure adenocarcinoma. The BAC and general lung transplantation cohorts had similar 30-day mortality (10% vs 7%, p = 0.44) and 5-year survival (57% vs 50%, p = 0.66).
CONCLUSIONS:
Survival after lung transplantation for BAC appears to be consistent with that of lung transplantation for other diagnoses and is better than that reported with chemotherapy. Further study is warranted to identify the subgroup of patients with lung cancer who will have a maximum survival advantage after lung transplantation.
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