Exposure to solvents in health care workers: assessment of the hepatic effects.

Caciari T, Casale T, Pimpinella B, Montuori L, Trove' L, Tomei G, Capozzella A, Schifano MP, Fiaschetti M, Scala B, Tomei F, Rosati MV.

Source

Department of Anatomy, Histology, Medical-Legal and the Orthopedics, Unit of Occupational Medicine, Sapienza University of Rome, Italy. Department of Psychiatric and Psychological Science, Sapienza University of Rome, Italy.

Abstract

Objectives: The use of organic solvents has been linked to pathologies of different apparatuses. The purpose of this study is to analyze the liver damage induced by organic solvents.

Materials and Methods: We analyzed 556 workers, 278 exposed to organic solvents (group 1) and 278 not exposed to organic solvents (group 2). The exposed group was further divided into 2 subgroups: group 1A (139 workers exposed to considerable doses) and group 1B (139 workers exposed to negligible doses). Mean and standard deviation of some liver parameters was calculated. Statistically significant differences between the liver parameters in the different groups and subgroups were detected using the t-test. Multiple linear regression models were used to examine the associations between laboratory parameters and the independent variable.

Results: The data so far obtained showed the existence of statistically significant differences with regard to the total protein, total bilirubin, transaminase GOT and GPT, Gamma Glutamyl Transferase (gamma-GT).

Conclusions: Our results confirm that exposure to solvents can alter some liver parameters. The blood tests we used can be useful tool for the assessment of the actual occupational hazards and to verify the effectiveness of the measures taken for the prevention and protection.

TimAllenMDJD

Sunday, March 10, 2013