Expert Rev Respir Med. 2013 Aug 27. [Epub ahead of print]
Mitochondria in lung diseases.
Abstract
Mitochondria
are autonomous cellular organelles that oversee a variety of functions
such as metabolism, energy production, calcium buffering and cell fate
determination. Regulation of their morphology and diverse activities
beyond energy production are being recognized as playing major roles in
cellular health and dysfunction. This review is aimed at summarizing
what is known regarding mitochondrial contributions to pathogenesis of
lung diseases. Emphasis is given to understanding the importance of
structural and functional aspects of mitochondria in both normal
cellular function (based on knowledge from other cell types) and in
development and modulation of lung diseases such as asthma, COPD, cystic fibrosis
and cancer. Emerging techniques that allow examination of mitochondria,
and potential strategies to target mitochondria in the treatment of
lung diseases are also discussed.
No comments:
Post a Comment