From MD Anderson: Teaching an old dog new tricks: drug repositioning in small cell lung cancer

Cancer Discov. 2013 Dec;3(12):1333-5. doi: 10.1158/2159-8290.CD-13-0790.

Teaching an old dog new tricks: drug repositioning in small cell lung cancer.

Wang J, Byers LA.

Source

1Departments of Bioinformatics and Computational Biology and 2Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Abstract

Summary: Jahchan and colleagues report the use of a biostatistical analysis to identify effective therapeutics for small cell lung cancer (SCLC). Their results reveal a new use for the tricyclic antidepressant imipramine in SCLC and shed light on the therapeutic potential of drug repositioning in cancer and other diseases.