- The Ohio State University, Columbus, OH.
Abstract
PURPOSE:
To evaluate yoga's impact on inflammation, mood, and fatigue.
PATIENTS AND METHODS:
A
randomized controlled 3-month trial was conducted with two
post-treatment assessments of 200 breast cancer survivors assigned to
either 12 weeks of 90-minute twice per week hatha yoga classes or a
wait-list control. The main outcome measures were
lipopolysaccharide-stimulated production of proinflammatory cytokines
interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and
interleukin-1β (IL-1β), and scores on the Multidimensional Fatigue
Symptom Inventory-Short Form (MFSI-SF), the vitality scale from the
Medical Outcomes Study 36-item Short Form (SF-36), and the Center for
Epidemiological Studies-Depression (CES-D) scale.
RESULTS:
Immediately post-treatment, fatigue
was not lower (P > .05) but vitality was higher (P = .01) in the
yoga group compared with the control group. At 3 months post-treatment, fatigue
was lower in the yoga group (P = .002), vitality was higher (P = .01),
and IL-6 (P = .027), TNF-α (P = .027), and IL-1β (P = .037) were lower
for yoga participants compared with the control group. Groups did not
differ on depression at either time (P > .2). Planned secondary
analyses showed that the frequency of yoga practice had stronger
associations with fatigue
at both post-treatment visits (P = .019; P < .001), as well as
vitality (P = .016; P = .0045), but not depression (P > .05) than
simple group assignment; more frequent practice produced larger changes.
At 3 months post-treatment, increasing yoga practice also led to a
decrease in IL-6 (P = .01) and IL-1β (P = .03) production but not in
TNF-α production (P > .05).
CONCLUSION:
Chronic inflammation may fuel declines in physical function leading to frailty and disability. If yoga dampens or limits both fatigue and inflammation, then regular practice could have substantial health benefits.
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