CRISPR J. 2019 Oct;2(5):293-298. doi: 10.1089/crispr.2019.0042.

Societal and Ethical Impacts of Germline Genome Editing: How Can We Secure Human Rights?

Halpern J¹, O'Hara SE², Doxzen KW³, Witkowsy LB³, Owen AL².

Author information

1

UCSF-UCB Joint Medical Program, School of Public Health, Affiliate Innovative Genomics Institute, University of California, Berkeley, Berkeley, California.

2

School of Public Health, Innovative Genomics Institute, University of California, Berkeley, Berkeley, California.

3

Innovative Genomics Institute, University of California, Berkeley, Berkeley, California.

Abstract

Genome editing has opened up the possibility of heritable alteration of the human germline. The potential of this powerful tool has spurred a call for establishing robust regulatory frameworks to outline permissible uses of genome editing and to map a rational and ethical course. In response, major national scientific bodies and international organizations have convened and released comprehensive reports outlining recommendations for ethical regulatory frameworks. Significantly, these include an emphasis on public participation and the development of principles to guide future applications of genome editing. While essential, public input and principles are not sufficient to ensure ethical uses of this technology. We propose an approach that relies not only on agreed-upon principles and a democratic process but requires a Human Rights Impact Assessment to evaluate the potential burdens that such biomedical interventions may place on human rights.