Clin Geriatr Med. 2011 Aug;27(3):365-85.
Physiopathological mechanism of sarcopenia.
Walrand S, Guillet C, Salles J, Cano N, Boirie Y.
INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, F-63009, France; Université Clermont 1, UFR de Médecine, UMR 1019, UNH, Clermont-Ferrand, F-63001, France.
The etiology of sarcopenia is multifactorial but still poorly understood, and the sequelae of this phenomenon represent a major public health issue. Age-related loss of muscle mass can be counteracted by adequate metabolic interventions including nutritional intake and exercise training. Other strategies including changes in daily protein pattern, the speed of protein digestion, or specific amino acid supplementation may be beneficial to improve short-term muscle anabolic response in elderly people. A multimodal approach combining nutrition, exercise, hormones, and specific anabolic drugs may be an innovative treatment for limiting the development of sarcopenia with aging.
Copyright © 2011 Elsevier Inc. All rights reserved.