SPECIAL SECTION–PERSPECTIVES ON TARGETED THERAPIES FOR TREATMENT OF HUMAN CANCERS
Emerging Targeted Therapies in Cancer
Lucian R. Chirieac, MD
"The development of target-based therapies has dramatically changed the outlook of cancer treatment and increased the expectations for patients with cancer. Cancers that contain multiple genetic and epigenetic abnormalities are addicted to genes that promote their malignant behavior and cell survival. Targeted cancer therapies with monoclonal antibodies or small-molecule inhibitors interfere with cell proliferation and tumor spread to distant organs. Many of these therapies target proteins that are involved in cell signaling pathways, which form an intricate communication system that controls basic cellular functions, such as cell division, motility, responses to specific extracellular signals, and cell death."