"If we think about the history of obesity medications, we've seen plenty of lemons. Ephedra, Fen-phen, phenylpropanolamine, and sibutramine had to be withdrawn from the market because of cardiovascular toxicity. Rimonabant was approved for sale in Europe, but was never approved in the United States because of severe psychiatric side effects. At this time, Xenical is the only drug that is FDA-approved for obesity, and its use is limited by abdominal discomfort and steatorrhea. Why so many lemons? And what about Qnexa? Is it another lemon, or is it the peach we all want?"