From Kirtee Raparia and colleagues: Lymphoproliferative Neoplasms of the Lung

http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2012-0202-RA

Josette William, Daina Variakojis, Anjana Yeldandi, and Kirtee Raparia (2013) Lymphoproliferative Neoplasms of the Lung: A Review. Archives of Pathology & Laboratory Medicine: March 2013, Vol. 137, No. 3, pp. 382-391.

SPECIAL SECTION—CONTRIBUTIONS FROM THE ANATOMIC PATHOLOGY STAFF OF FEINBERG SCHOOL OF MEDICINE, NORTHWESTERN UNIVERSITY

Lymphoproliferative Neoplasms of the Lung: A Review

Josette William , MD, PhD; Daina Variakojis , MD; Anjana Yeldandi , MD; Kirtee Raparia , MD

From the Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.

Context.—Diagnosis and classification of lymphomas are based on the morphologic, immunologic, and genetic features that the lesional cells share with their normal B and T lymphocyte counterparts. Primary pulmonary lymphomas account for 0.3% of primary lung neoplasms and less than 0.5% of all lymphomas.

Objective.—To describe and summarize the clinical and histopathologic features of the primary pulmonary lymphoma and secondary involvement of the lung by lymphoma.

Data Sources.—Peer-reviewed published literature and personal experience.

Conclusions.—Diagnosis of clonal lymphoid proliferations in the lung has evolved owing to the greater utility of molecular and flow cytometric analysis of tissue. Further studies are needed to best define the clinical and prognostic features, as well as search for targeted therapy for these patients with rare neoplasms.