Thursday, February 28, 2013

Evaluating Animal Models: Some Taxonomic Worries

http://www.ncbi.nlm.nih.gov/pubmed/23444231


 2013 Feb 26. [Epub ahead of print]

Evaluating Animal Models: Some Taxonomic Worries.

Source

Centre for Values, Ethics and the Law in Medicine, University of Sydney, Sydney, Australia.

Abstract

The seminal 1993 article by LaFollette and Shanks "Animal Models in Biomedical Research: Some Epistemological Worries" introduced an influential taxonomy into the debate about the value of animal experimentation. The distinction they made between hypothetical and causal analog models served to highlight a concern regarding extrapolating results obtained in animal models to human subjects, which endures today. Although their taxonomy has made a significant contribution to the field, we maintain that it is flawed, and instead, we offer a new practice-oriented taxonomy of animal models as a means to allow philosophers, modelers, and other interested parties to discuss the epistemic merits and shortcomings, purpose, and predictive capacities of specific modeling practices.

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