From Anna Kurdowska and me: Interleukin 8 and Acute Lung Injury

http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2013-0182-RA

Timothy Craig Allen and Anna Kurdowska (2013) Interleukin 8 and Acute Lung Injury. Archives of Pathology & Laboratory Medicine In-Press.

Early Online Release

Interleukin 8 and Acute Lung Injury

Timothy Craig Allen , MD, JD; Anna Kurdowska , PhD

From the Departments of Pathology (Dr Allen) and Biochemistry (Dr Kurdowska), University of Texas Health Science Center at Tyler.

Acute lung injury is a complex clinical syndrome involving acute inflammation, microvascular damage, and increased pulmonary vascular and epithelial permeability, frequently resulting in acute respiratory failure culminating in often-fatal acute respiratory distress syndrome. Interleukin 8 (IL-8), a potent neutrophil attractant and activator, plays a significant role in acute lung injury via the formation of anti–IL-8 autoantibody:IL-8 complexes and those complexes' interaction with FcγRIIa receptors, leading to the development of acute lung injury by, among other possible mechanisms, effecting neutrophil apoptosis. These complexes may also interact with lung endothelial cells in patients with acute respiratory distress syndrome. Continuing research of the role of neutrophils, IL-8, anti–IL-8 autoantibody:IL-8 complexes, and FcγRIIa receptors may ultimately provide molecular therapies that could lower acute respiratory distress syndrome mortality, as well as reduce or even prevent the development of acute lung injury altogether.