U Mass's Armando Fraire debutes his "Five Top Stories" series in the July Archives: First up-Cytopathology

U Mass's Armando Fraire debutes his "Five Top Stories" series in the July Archives:

http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2013-0174-ED

Armando E. Fraire (2013) Five Top Stories in Anatomic Pathology: Stories From the Faculty at UMass Medical School and UMass Memorial Medical Center, Worcester, Massachusetts. Archives of Pathology & Laboratory Medicine: July 2013, Vol. 137, No. 7, pp. 886-886.

SPECIAL SERIES—FIVE TOP STORIES IN ANATOMIC PATHOLOGY

Five Top Stories in Anatomic Pathology: Stories From the Faculty at UMass Medical School and UMass Memorial Medical Center, Worcester, Massachusetts

Armando E. Fraire , MD

From the Department of Pathology, University of Massachusetts Medical School, Worcester.

First up-Cytopathology:

http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2012-0210-RA

Amy G. Zhou, Christopher L. Owens, Ediz F. Cosar, and Zhong Jiang (2013) Clinical Implications of Current Developments in Genitourinary Pathology. Archives of Pathology & Laboratory Medicine: July 2013, Vol. 137, No. 7, pp. 887-893.

SPECIAL SECTION—FIVE TOP STORIES IN ANATOMIC PATHOLOGY AND CYTOPATHOLOGY

Clinical Implications of Current Developments in Genitourinary Pathology

Amy G. Zhou , MD; Christopher L. Owens , MD; Ediz F. Cosar , MD; Zhong Jiang , MD

From the Department of Pathology, University of Massachusetts Medical School, Worcester.

Context.—Several developments in genitourinary pathology are likely to change our understanding and management of some genitourinary cancers considerably.

Objective.—To review 5 stories in genitourinary pathology: (1) fusion in the ETS (E26) gene family in prostatic adenocarcinoma; (2) insulin-like growth factor II messenger RNA-binding protein 3 (IMP3), an important prognostic biomarker for kidney and bladder cancers; (3) translocation renal cell carcinoma; (4) UroVysion fluorescence in situ hybridization test in urine cytology for detection of bladder cancer; and (5) the use of triple immunostaining for diagnosis of prostate cancer.

Data Sources.—Literature review and authors' personal experiences.

Conclusions.—Many scientific findings have contributed recently to the understanding of the natural pathogenesis and progression of genitourinary cancers. This translational research helps in diagnosing, predicting, and potentially, treating genitourinary cancers.

http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2012-0258-SA

Andrew H. Fischer, Cynthia C. Benedict, and Mojgan Amrikachi (2013) Five Top Stories in Cytopathology. Archives of Pathology & Laboratory Medicine: July 2013, Vol. 137, No. 7, pp. 894-906.

SPECIAL SECTION—FIVE TOP STORIES IN ANATOMIC PATHOLOGY AND CYTOPATHOLOGY

Five Top Stories in Cytopathology

Andrew H. Fischer , MD; Cynthia C. Benedict , MD; Mojgan Amrikachi , MD

From the Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts (Dr Fischer); the Department of Cytopathology, DCL Medical Laboratories, Inc, Indianapolis, Indiana (Dr Benedict); and the Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, Texas (Dr Amrikachi).

Context.—Cytology relies heavily on morphology to make diagnoses, and morphologic criteria have not changed much in recent years. The field is being shaped predominantly by new techniques for imaging and for acquiring and processing samples, advances in molecular diagnosis and therapeutics, and regulatory issues.

Objective.—To review the importance of classical morphology in the future of cytopathology, to identify areas in which cytology is expanding or contracting in its scope, and to identify factors that are shaping the field.

Data Sources.—Literature review.

Conclusions.—Five stories paint a picture in which classical cytomorphology will continue to have essential importance, both for diagnosis and for improving our understanding of cancer biology. New endoscopy and imaging techniques are replacing surgical biopsies with cytology samples. New molecularly targeted therapies offer a chance for cytology to play a major role, but they pose new challenges. New molecular tests have the potential to synergize with, but not replace, morphologic interpretation of thyroid fine-needle aspirations. Ultrasound-guided fine-needle aspiration performed by cytopathologists is opening a new field of “interventional cytopathology” with unique value. For the productive evolution of the field, it will be important for cytopathologists to play an active role in clinical trials that document the ability of cytology to achieve cost-effective health care outcomes.