Risk of using CT scan as an outcome surrogate in Cystic Fibrosis patients

http://www.ncbi.nlm.nih.gov/pubmed/22357879

Radiology. 2012 Mar;262(3):746-9.
CT as an Outcome Surrogate in Patients with Cystic Fibrosis: Does the Effort Justify the Risks?
Hernanz-Schulman M.
Source
Department of Diagnostic Imaging, Monroe Carell Jr Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, 2200 Children's Way, Nashville, TN 37232.

"Although the potential effects of radiation in monitoring disease activity in patients with cystic fibrosis may never be completely eliminated, radiation dose can be markedly lowered by manipulating the technical parameters of the examination and by using state-of-the art equipment such that effective dose at CT approaches that of chest radiography; undersampling, as tested by Loeve et al and others is still applicable, but it should be used judiciously based on appropriate data and carefully applied in longitudinal patient evaluation."