Mesothelioma risk after 40 years since first exposure to asbestos: a pooled analysis ("...no one survives long enough for the excess risk to disappear.")

Thorax. 2014 May 19. pii: thoraxjnl-2013-204161. doi: 10.1136/thoraxjnl-2013-204161. [Epub ahead of print]

Mesothelioma risk after 40 years since first exposure to asbestos: a pooled analysis.

Reid A1, de Klerk NH2, Magnani C3, Ferrante D3, Berry G4, Musk AW5, Merler E6.

Author information

• 1School of Public Health, Curtin University, Bentley, Western Australia.
• 2School of Population Health, The University of Western Australia, Crawley, Western Australia The Telethon Institute for Child Health Research and the Centre for Child Health Research, The University of Western Australia, Crawley, Western Australia.
• 3Cancer Epidemiology Unit, CPO Piemonte and Department of Translational Medicine of the University of Eastern Piedmont, Novara, Italy.
• 4The School of Public Health, University of Sydney, Sydney, Australia.
• 5School of Population Health, The University of Western Australia, Crawley, Western Australia.
• 6Venetian Mesothelioma Registry, Occupational Health Unit, Local Health Authority of Padua, Padua, Italy.

Abstract

BACKGROUND:

The risk of malignant mesothelioma (MM) increases proportionally to the cumulative exposure, and to the 3rd or 4th power of time since first exposed, to asbestos. However, little is known about the risk of MM after more than 40 years since first exposure because most epidemiological studies do not have follow-up for sufficient periods of time.

METHODS:

The data from six cohort studies of exposed workers and two cohorts with residential exposure have been pooled. A nested case control design matched cases and controls on calendar period and age. Conditional logistic regression modelled the relationship between time since first exposure and risk of MM.

RESULTS:

The combined data consisted of 22 048 people with asbestos exposure (5769 women), 707 cases of pleural MM (165 in women) and 155 cases of peritoneal MM (32 in women). Median time since first exposure for pleural MM cases was 38.4 years (IQR 31.3-45.3). Median duration of exposure for pleural MM cases was 3.75 years (IQR 0.7-18.2). The rate and risk of pleural MM increased until 45 years following first exposure and then appeared to increase at a slower power of time since first exposure. The rate of increase in peritoneal MM over the 10-50 years since first exposure continued to increase.

CONCLUSIONS:

Exposure to asbestos confers a long-term risk of developing pleural and peritoneal mesothelioma which increases following cessation of exposure. While the rate of increase appears to start to level out after 40-50 years no one survives long enough for the excess risk to disappear.