"The prevalence of vascular dysfunction is proportional to the accumulation of visceral fat (fat around the organs)..."

Obesity-Related Blood Vessel Dysfunction

"The prevalence of vascular dysfunction is proportional to the accumulation of visceral fat (fat around the organs); a phenomenon known as a “metabolically unhealthy obesity” phenotype. On the other hand, a phenotype predominantly characterized by subcutaneous adipose tissue (STA, fat directly underneath the skin) is classified as “metabolically healthy obesity” because the STA may act against potentially toxic lipids. Therefore, the pattern of obesity plays a role in one’s cardiometabolic risk profile. The formation of new vascular networks is crucial in the process of the development of healthy adipose tissue since the endothelial cells tightly regulate it; this process of known as angiogenic-based adipose tissue differentiation. In this way, visceral adipose tissue (VAT) has a higher abundance of endothelial cells and increased vascular density, but also has more potent pro-inflammatory properties that cause metabolic and vascular complications related to obesity."