Adv Emerg Nurs J. 2014 Jul-Sep;36(3):226-38; quiz 239-40. doi: 10.1097/TME.0000000000000029.
- 1North Carolina Public Health Preparedness and Response, North Carolina Department of Health and Human Services, Raleigh (Dr Weant); University of Kentucky HealthCare, Departments of Pharmacy Services and Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington (Drs Bailey and Justice and Ms Fleishaker).
Abstract
Bioterrorism presents a real and omnipresent risk to public health throughout the world. More than 30 biological agents have been identified as possessing the potential to be deployed in a bioterrorist attack. Those that have been determined to be of the greatest concern and possess the greatest potential of use in this arena are known as the Category A agents: Bacillus anthracis (anthrax); Variola major (smallpox); Yersinia pestis (plague); Francisella tularensis (tularemia); viral hemorrhagic fevers; and Clostridium botulinum toxin (botulism toxin). Although the Centers for Disease Control and Prevention utilizes surveillance systems to identify illnesses, the weight of diagnosing, effectively treating, and notifying the appropriate public health officials lies squarely on the shoulders of emergency care personnel. Part I of this two-part review will focus on the clinical presentation and treatment of anthrax, plague, and tularemia. The subsequent Part II of this review will discuss smallpox, viral hemorrhagic fevers, botulism toxin, and the provision of mass prophylaxis.
- 1KentuckyOne Health, University of Louisville, Louisville, Kentucky (Dr Weant); University of Kentucky HealthCare, Departments of Pharmacy Services and Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington (Drs Bailey, and Fleishaker); and Charleston Area Medical Center, Department of Pharmacy, Charleston, West Virginia (Dr Justice).
Abstract
Although several biological agents have been recognized as presenting a significant threat to public health if used in a bioterrorist attack, those that are of greatest importance are known as the Category A agents: Bacillus anthracis (anthrax); variola major (smallpox); Yersinia pestis (plague); Francisella tularensis (tularemia); ribonucleic acid viruses (hemorrhagic fevers); and Clostridium botulinum (botulism toxin). In the previous issue, Part I of this review focused on the clinical presentation and treatment of anthrax, plague, and tularemia. In this second part of this 2-part review of these agents, the focus is on the clinical presentation and treatment of smallpox, viral hemorrhagic fevers, and botulism toxin. The utilization of mass prophylaxis to limit the morbidity and mortality associated with all these agents is also discussed along with the role emergency care personnel play in its implementation.
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