Alain C. Borczuk (2018) Uncommon Types of Lung Carcinoma With Mixed Histology: Sarcomatoid Carcinoma, Adenosquamous Carcinoma, and Mucoepidermoid Carcinoma. Archives of Pathology & Laboratory Medicine: August 2018, Vol. 142, No. 8, pp. 914-921.

SPECIAL SECTION—2017 (10TH BIENNIAL) MEETING OF THE PULMONARY PATHOLOGY SOCIETY, PART I

Uncommon Types of Lung Carcinoma With Mixed Histology: Sarcomatoid Carcinoma, Adenosquamous Carcinoma, and Mucoepidermoid Carcinoma

Alain C. Borczuk, MD

From Weill Cornell Medicine, New York, New York.

The author has no relevant financial interest in the products or companies described in this article.

Presented in part at the 2017 Pulmonary Pathology Society Biennial Meeting; June 13–16, 2017; Chicago, Illinois.

Corresponding author: Alain C. Borczuk, MD, Weill Cornell Medicine, 1300 York Ave, ST10-1000A, New York, NY 10065 (email: Alb9003@med.cornell.edu).

Context.— Lung tumors are histologically heterogeneous, but classification of lung carcinoma has prognostic impact and increasingly, specific molecular correlates.

Objective.— To update the gross, microscopic, and molecular pathology of unusual lung carcinomas to assure accurate classification. In entities with mixed histology, the recognition of specific features or rare patterns is critical to diagnosis. These diagnoses can identify tumors with aggressive clinical behavior, and diagnostic pitfalls can therefore result in underdiagnosis of these already rare entities. Incorrect classification of more indolent tumors into the more aggressive categories can also occur. In the area of molecular pathology, these unusual tumors have a specific spectrum of molecular alterations.

Data Sources.— PubMed searches for lung and sarcomatoid carcinoma, pleomorphic carcinoma, blastoma, carcinosarcoma, and adenosquamous and mucoepidermoid carcinoma were undertaken and this information was integrated with clinical experience of the author.

Conclusions.— These uncommon carcinomas have specific clinicopathologic features, and attention to their gross and microscopic pathology leads to classification with important associated molecular findings.