Nature Reviews Clinical Oncology 10, 428 (August 2013) | doi:10.1038/nrclinonc.2013.118
Basic research: Understanding why the naked mole rat is cancer resistant
Abstract
The naked mole rat's lifespan of 30 years is remarkable, as is its natural resistance to cancer. Researchers have now identified a mechanism responsible for the latter: high levels of high-molecular-mass hyaluronan secreted from fibroblasts, which accumulates because of decreased activity of hyaluronan-degrading enzymes.
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